Roussel Uclaf

Michel Hardy

Daniel Humbert

Lucien Nedelec

Vesperto Torelli

Andre Poittevin

A novel process for the preparation of 17.beta.-hydroxyacetyl-17.alpha.-ol-steroids of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted with halogen or an oxygen or nitrogen function and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.2 is alkyl of 1 to 4 carbon atoms and the A,B,C and D rings may contain one or more double bonds and are optionally substituted with at least one member of the group consisting of hydroxy, keto, halogen, alkyl and alkoxy of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms which compounds are generally known of the cortisonic type with known properties.

Preparation of 17.beta.-hydroxyacetyl-17.alpha.-ol-steroids

Non-toxic, pharmaceutically acceptable acid addition salts of a compound of the formula ##STR1## wherein R is an alkyl of 2 to 12 carbon atoms and R' is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and acyl of an organic carboxylic acid of 1 to 12 carbon atoms having antilipolytic activity and a very prolonged vasodilatatory activity.

Salts of 2-alkylthiazole-5-methanol derivatives

Novel thiazole derivatives of the formula ##STR1## wherein R is alkyl of 2 to 12 carbon atoms and R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and acyl of an organic carboxylic acid of 1 to 12 carbon atoms having hypolipemiant activity with a very prolonged vasodilatatory activity and their preparation.

Hypolipemiant composition and method using thiazole-5-methanols

Novel 2-hydroxymethyl-thiazole-5-carboxylic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkylcarbonyl of 2 to 5 carbon atoms, benzoyl, phenyl optionally substituted with at least one halogen and ##STR2## R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, Z is selected from the group of phenyl and phenoxy optionally substituted with at least one halogen and R' is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and alkali metals, alkaline earth metals and aluminum salts, having a marked hypolipemiant activity as well as a clear vasodilatatory activity and which may possess hypocholesterolemiant activity and their preparation.

2-Hydroxymethyl-thiazole-5-carboxylic acid derivatives

Novel thiazole derivatives of the formula ##EQU1## wherein R is alkyl of 2 to 12 carbon atoms and R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and acyl of an organic carboxylic acid of 1 to 12 carbon atoms having hypolipemiant activity with a very prolonged vasodilatatory activity and their preparation.

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Maisons-Alfort, France

Michel Hardy