Ucb S.a.

Novasep

Daicel Chemical Industries, Ltd.

Michel Hamende

Emile Cavoy

Vincent Zimmermann

Michel Deleers

Roger-Marc Nicoud

Jean-Pierre Canvat

Olivier Ludemann-Hombourger

Vincent Zimmerman

Sylvie Lehoucq

Marc Chatel

Tooru Futagawa

Laurent Rebier

The present invention relates to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide by separation of a racemic mixture using multiple column chromatography.

Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide

Process for preparing (S) and (R)&#x2014;2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide

A method and device for chromatographic separation producing at least two fractions are provided, in which: (i) the solvent is at least partially evaporated from the fractions produced; (ii) the solvent vapours thus produced are separated; stage (i) of the method being carried out, for at least one of the fractions, at least partially with the separated solvent vapours originating from one of the other evaporated fractions.

Chromatography method and device with recovery of solvent

The invention relates to a process for separating at least one component of a mixture in a simulated moving bed, in which each of the chromatographic columns that contains an adsorbent has a ratio of L (length) to D (diameter) of between 0.01 and 0.34, and the ratio of L (length in n columns) to D (diameter) is between 0.06 and 2.3. It is possible to apply an axial dynamic pressure on each of the upper columns that exceeds the pressure drop of all of the columns.

Process for separation in a simulated moving bed of at least one component in columns that have a suitable length to diameter ratio

The present invention relates to a process for preparing (S)- and (R)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide and (R)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide. According to this process, the enantiomeric resolution of the racemic mixture of .alpha.-ethyl-2-oxo-1-pyrrolidineacetamide is carried out by simulated mobile bed chromatography, using at least three columns filled with chiral stationary phase. This process makes it possible to achieve good production efficiency on the industrial scale.

Process for preparing (s)- and

Levetiracetam is prepared by optical resolution of etiracetam by means of preparative high performance liquid chromatography or continuous simulated moving bed chromatographic system using silica gel supporting amylose tris(3,5-dimethylphenylcarbamate) as a packing material.

Process for the preparation of levetiracetam

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Brussels, Belgium

Michel Hamende