Massachusetts Institute of Technology

Affinity Biosensors, LLC

Michel Godin

Scott R Manalis

Kenneth Babcock

Thomas P Burg

Thomas Burg

William H Grover

Yao-Chung Weng

Andrea Kristine Bryan

Philip Dextras

Sungmin Son

Method for measuring a target particle property. A suspended microchannel resonator is calibrated to determine the relationship between a detected mass and a resonance frequency shift of the resonator. The target particle is suspended in a fluid and introduced into the resonator, and the resonator frequency shift due to the particle is measured. Target particle mass is calculated from the resonator frequency shift, the target particle density, and the fluid density. A target particle property such as size or volume is determined from the calculated target particle mass.

Method and apparatus for measuring particle characteristics through mass detection

Mass cytometry method. In one aspect, the method includes providing a sample having at least one cell type and mixing the sample with material such as nanoparticles functionalized with affinity molecules for the at least one cell type. The sample is transported through a suspended microchannel resonator to record a mass histogram and a cell count for the at least one cell type is determined from the histogram.

Flow cytometry methods and immunodiagnostics with mass sensitive readout

Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods and for changing the fluid properties within the SMR during the extended periods. Methods include techniques to provide for cell growth over time and over time in response to changing fluid properties to aid in determining parameters such as drug resistance and drug susceptibility.

Method and apparatus for extended time and varying environment measurements of single particles in microfluidic channels

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Beaconsfield, Canada

Michel Godin