Roussel Uclaf

Hoechst Marion Roussel

Other

Hoechst Marion Roussol

Michel Fortin

Francois Clemence

Odile Le Martret

Francoise Delevallee

Alain Corbier

Gilles Hamon

Jean-Luc Haesslein

Daniel Frechet

Jacques Guillaume

Jean-Paul Vevert

Simone Jouquey

Giulio Galliani

Fernando Barzaghi

Emilio Toja

Pierre Deprez

Anne-Marie Moura

Bertrand Heckmann

Carlo Gorini

Jean Paul Vevert

Jean C Caille

Francedillaois Clemence

Jidong Zhang

Francis Petit

Philippe Cosquer

Stanislas Didierlaurent

Serge Droux

Fran&ccedil;ois Clemence

Jean Luc Haesslein

Fran&ccedil;oise Delevallee

Anne M Moura

A compound selected from the group consisting of enantiomers and diastereoisomer forms and mixtures thereof of the formula

Substituted with an N-methyl benzene-acetamide and 1-pyrrolidinyl

Compounds of the formula ##STR1## in all possible racemic, enantiomeric and diastereoisomeric forms and their non-toxic, pharmaceutically acceptable salts with acids and bases having antagonistic properties for angiotensin II receptors and a process and novel intermediates for their properties.

Nitrogenous bicycles

Novel N-substituted quinolines of the formula useful in the treatment of cardiovascular illnesses having an alteration in the vasomotricity and a process for their preparation.

N-substituted quinolines

Products of formula (1), wherein R.sub.1 is particularly ##STR1## alkyl, alkylthio or alkoxy; R.sub.2 is particularly halogen, --S--R, --O--R or --C(OH)(R)--COOH, where R is alkyl or alkenyl; R.sub.3 is particularly carboxy, acyl, halogen, alkyl, alkenyl or alkylthio; and R.sub.4 is particularly --(CH.sub.2).sub.m1 --COOR.sub.4, --(CH.sub.2).sub.m1 --CONHR.sub.14, --(CH.sub.2).sub.m1 --CN, --SO.sub.2 --NH--SO.sub.2 --R.sub.14, 13 NH--SO.sub.2 --R.sub.14, --PO.sub.3 R.sub.14, or --NH--SO.sub.2 --CF.sub.3, where m1 is 0-4 and R.sub.14 is hydrogen, alkyl or alkenyl; are useful for preparing pharmaceutical compositions for treating disorders resulting from abnormal stimulation of angiotensin II receptors AT.sub.1 and AT.sub.2.

Imidazole-5-carboxamides

Acid pyrazole derivatives, preparation method therefor, use thereof as

Quinoline compounds

Method of preventing abnormal stimulation of AT.sub.1 and AT.sub.2

Tetrasubstituted imidazoles

The bicyclic derivatives of pyridines of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts and a process and intermediates for their preparation which compounds are inhibitors of angiotensin II effects, particularly a vasoconstrictor activity.

Method for inhibiting vasoconstriction

Novel compounds of the formula ##STR1## wherein the, substituents are defined as in the specification and their non-toxic, pharmaceutically acceptable salts which inhibit the effects of angiotensin II in warm-blooded animals.

Sulphorous derivatives of imidazole, their preparation process, the new

Products of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent:

Derivatives of pyridone, their preparation process, the new

Method of inhibiting angiotensin effects

The invention relates to the products: ##STR1## in which: R.sub.1 =alkyl, alkenyl, alkynyl, alkylthio,

Sulphorous derivatives of imidazole and their use as medicaments

A compound selected from the group consisting of all possible racemic, enantiomeric and diastereoisomeric forms of a compound of the formula ##STR1## wherein E and G together form a group selected from the group: ##STR2## consisting of a) ##STR3## or, if appropriate, its tautomer ##STR4## and ##STR5## or E is --COOR.sub.3 and G is ##STR6## wherein A, Y, R, Ra, R.sub.1 and R.sub.2 are as defined in the specification.

Pyrrolidinyl pyridones for treating pain

Novel bicyclic compounds in all possible racemic, enantiomeric and diasteroisomeric forms of the formula ##STR1## having antagonistic properties for angiotensin II receptors and novel intermediates and process for their preparation.

Nitrogenous bicyclic derivatives substituted with benzyl

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Paris, France

Michel Fortin