Societe D'expansion Scientifique Expansia

Societe De Conseils De Recherches Et D'applications Scientifiques (s.c.r.a.s.)

Societe De Conseils De Recherches Et D'applications Scientifiques

Societe D'expansion Scientifque Expansia

Michel Follet

Bernard Calas

Robert Jacquier

Marc Bonato

Jacques Daunis

Christian Aspisi

Joseph Parello

Jean Mery

Hanitra Naharisoa

This invention relates to solid phase peptide synthesis. Solid phase peptide synthesis is accomplished on polyacrylic resins (such as those described in EP 0 079 812 and EP 0 081 408 which correspond to U.S. Pat. Nos. 4,436,874 and 4,439,545 respectively) by a method which includes in the coupling protocol steps of washing the resin in water and/or aqueous solution(s).

Solid phase peptide synthesis using a polyacrylic support in aqueous

This invention relates to catechol derivatives having the general formula ##STR1## wherein R represents various substituents, to a process for the preparation of the same comprising reacting S-(3,4-dihydroxyphenyl)-isothiourea, which has the formula II, with a tosylate of the general formula III ##STR2## and to therapeutical compositions wherein the active ingredient is one of these compounds.

Catechol derivatives, a process of preparation thereof, and

This invention relates to bicyclic catechol derivatives having the general formulae I and II ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and Z represent various substituents, to a preparation process of the same comprising reacting a compound of formula III ##STR2## wherein R.sub.1 and R.sub.2 have the meanings given above with an appropriately substituted propionic or butyric acid (or an ester or a salt of the same) of formula IV ##STR3## wherein R.sub.3 has the meaning given above, and to therapeutical compositions wherein the active ingredient is one of these compounds.

Lipoxygenase and cyclogenase inhibiting thiachromen and thiepan

The invention relates to new reticulated statistic acrylic copolymers that may be used in a very wide range of solvents (water, methylene chloride, chloroform, methanol, ethanol, dimethylformamide, pyridine,) stable between pH 1 and pH 14, to preparation process thereof and to their use in ion exchange chromatography.

Acrylic copolymers of N-acryloylpolymethyleneimines or

The present invention relates to new amino-functionalized acrylic copolymers, their preparation and their use in peptide synthesis.

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Aramon, France

Michel Follet