Akzo N.v.

Riom Laboratoires C.e.r.m. 'rl-cerm' S.a.

Riom Laboratories C.e.r.m.

Riom Laboratories - Cerm S.a.

Riom Laboratories C.e.r.m. 'rl-c.e.r.m.' S.a.

Michel Combourieu

Andre J Monteil

Jean-Claude Laigle

Nadine Simbille

Jacques A Simond

Yvon Bernet

Norbert Busch

Patrick Carlier

Claude Poisson

Marie-Paule Landes

The invention concerns an isochromane derivative having the general formula I ##STR1## in which R.sub.1 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, or CF.sub.3, or as two adjacent substituents together a methylenedioxy group;

Isochromane derivatives

The invention relates to neuroleptic/antidepressant 4-[4- or 6-(trifluoromethyl)-2-pyridinyl]-1-piperazinylalkyl substituted lactam derivatives having the general structure of formula I: ##STR1## wherein one of the groups R.sub.1 and R.sub.2 is CF.sub.3, and the other is hydrogen or CF.sub.3 ;

4-[4- or 6-(trifluoromethyl-2-pyridinyl)]-1-piperazinylalkyl substituted

N,N-dimethyl-N'-benzoyl-N'-(2,3-dihydrobenzofuran-2-ylmethyl)1,3-propanedia mine of formula: ##STR1## and its pharmaceutically acceptable salts, in racemic form or in the form of enantiomers, which compounds have anti-arrhythmic properties.

1,3-propanediamine derivatives and antiauhythnic pharmaceutical

The present invention relates to new compounds of the general formula: ##STR1## in which Ar represents thienyl, furyl, pyridyl or an optionally substituted phenyl group,

3-alkoxy-2-(N-pyrrolidino)-N-pyrimidinyl- or -N-pyrazinolpropylamines

Compounds of the formula: ##STR1## in which X represents one or two radicals selected from halogen, hydroxyl, alkoxy, alkyl, trifluoromethyl or methylenedioxy radicals, and their pharmaceutically acceptable salts, which may be used in the treatment of cardiovascular disturbances such as angina pectoris, hypertension and rhythmic disorders.

2-(N-pyrrolidino)-3-isobutoxy-n-substituted-phenyl-n-benzyl-propylamines,

The invention is dealing with antispasmodic compounds of the formula I ##STR1## in which R.sub.1 denotes H, halogen or a linear or branched C.sub.1 to C.sub.3 alkoxy or alkyl group, R.sub.2, R.sub.3 and R.sub.4 separately denote a linear or branched C.sub.1 to C.sub.4 alkyl group or R.sub.2 and R.sub.3 together with the nitrogen atom to which they are bound form a saturated heterocyclic radical, Z denotes a linear or branched C.sub.1 to C.sub.6 alkylene group and X.sup.- denotes an anion, preferably a halogen ion, and is dealing with intermediates in the preparation of the compounds of formula I.

Hexahydrodibenzodioxane compounds and pharmaceutical compositions

The present invention relates to new compounds of the general formula: ##STR1## in which X represents oxygen or sulphur and R represents a linear or branched alkyl group with 1 to 7 carbon atoms, and pharmaceutically acceptable acid addition salts thereof, having valuable cardiovascular properties.

3-Alkoxy-2-(N-pyrolidino)-N-pyridyl-N-furyl(or thienyl) methyl-pyropyl

The present invention is dealing with compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof, in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are identical or different and represent hydrogen, halogen, lower alkyl or alkoxy or trifluoromethyl; R.sub.5 represents hydrogen or lower alkyl, X represents hydrogen and Y represents hydroxy, or X and Y together represent oxygen and Ar represents an optionally substituted aromatic moiety, having potent anti-bronchoconstrictor properties.

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Aurillac, France

Michel Combourieu