Metabolic Explorer

Carbios

Other

Evonik Degussa Gmbh

Michel Chateau

Philippe Soucaille

Rainer Figge

Alain Marty

Céline Raynaud

Gwénaëlle Bestel-Corre

Sophie Duquesne

Cédric Boisart

Marie-Laure Desrousseaux

Fabien Lux

Helene Texier

Benjamin Gonzalez

Jean-Philippe Rousselle

Mediha Aloui Dalibey

Olivier Zink

Jean-Yves Dubois

Isabelle Meynial-Salles

Guillaume Barbier

Hélène Texier

Elodie Guemard

Madiha Aloui Dalibey

Philippe Noel Paul Soucaille

Rainer Martin Figge

Philippe Nöel Paul Soucaille

The present invention relates to a masterbatch composition comprising high concentration of biological entities having a polymer-degrading activity and uses thereof for manufacturing biodegradable plastic articles.

Masterbatch composition comprising a high concentration of biological entities

The present invention relates to processes for degrading plastic products and the uses thereof. The processes of the invention particularly comprise a step of amorphizing a plastic product prior to a step of depolymerization. The processes of the invention are particularly useful for degrading a plastic product comprising polyethylene terephthalate and/or polylactic acid. The invention also relates to a method of producing monomers and/or oligomers from a plastic product comprising at least one polyester, particularly polyethylene terephthalate and/or polylactic acid, comprising submitting the plastic product both to an amorphization step and to a depolymerization step.

Process for degrading plastic products

The present invention relates to plastic composition comprising at least one polyester, biological entities having a polyester-degrading activity and at least an anti-acid filler, wherein the biological entities represent less than 11% by weight, based on the total weight of the plastic composition, and uses thereof for manufacturing biodegradable plastic articles.

Process for preparing a biodegradable plastic composition

Process for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulfur. The microorganism and/or the culture medium are modified in such way that the methionine/carbon source yield is increased. The isolation of methionine or its derivates from the fermentation medium is also described.

Increasing methionine yield

A method of producing methionine, derivatives or precursors thereof includes culturing a modified microorganism in a culture medium comprising a source of carbon and a source of sulfur; and recovering methionine from the culture medium, wherein said modified microorganism has an increased expression of cysE gene encoding serine acetyltransferase, metH gene encoding methionine synthase and metF gene encoding 5,10-methylenetetrahydrofolate reductase compared to expression of the cysE, metH and metF genes in an unmodified microorganism.

Methods for producing methionine by culturing a microorganism modified to enhance production of cysteine

The present invention relates to the use of recombinant homoserine transsuccinylase enzymes with altered feedback sensitivity (MetA*) and possibly recombinant S-adenosyl methionine synthetase enzymes with reduced activity (MetK*) for the production of methionine, its precursors or derivatives thereof.

Recombinant enzyme with altered feedback sensitivity

A method of producing methionine, derivatives or precursors thereof comprising culturing a microorganism modified to enhance production of cysteine in a culture medium comprising a source of carbon and a source of sulfur and recovering methionine from the culture medium. A microorganism for fermentative production of methionine or its derivatives in which production of methionine or derivatives thereof, wherein the microorganism enhances production of cysteine.

The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in NADPH-consuming biotransformation methods. Said strains are characterized in that one or more NADPH-oxidizing activities are limited.

Optimised micro-organism strains for NADPH-consuming biosynthetic pathways

The present invention is directed to a method for the preparation of evolved microorganisms permitting the creation or modification of metabolic pathways. Strains of evolved microorganisms and evolved genes obtained by the method are also provided. The invention is also directed to the use of evolved microorganisms, genes or proteins in a biotransformation process.

Method for the preparation of an evolved microorganism for the creation or the modification of metabolic pathways

A door blocking device comprises a bar, which extends along the edge of the door jamb, and a formed section for housing the bar, which formed section is fast with said edge and so shaped as to allow the bar to move, with only a small amount of friction, under the control of an actuating member, between a door blocking position and a door releasing position. The bar is equipped with means for returning it to the blocking position, and the actuating member drives it against the returning force in order to bring it in the releasing position. The blocking bar is equipped with a locking device comprising an elongated flat rod which, by a pivoting movement under the action of return springs, takes up a slanted position behind the bar and locks it in the door-blocking position. The bar actuating member can drive said bar back to the releasing position after controlling the retraction of the flat rod by means of a bent lever pivoting through the bar.

Door blocking device

The invention relates to a lock comprising an assembly of identification plates provided with coding notches. A flat key, presenting a coded side, pushes the plates until their notches are brought into alignment, in which a feeler then comes into mesh by a rectilinear edge. The plates, continuing to slide under the thrust of the key, take along, via the feeler, a member for controlling the bolt. An alarm device indicates any introduction of an unsuitable key.

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Riom, France

Michel Chateau