Merck Patent Gmbh

Merck Patent Gesellschaft MIT Beschrankter Haftung

Merck Sante

Michel Brunet

Daniel Guerrier

Francis Contard

Jean-Jacques Zeiller

Marc Noblet

Gerd Bartoszyk

Hartmut Greiner

Yves Bonhomme

Jean-Jacques Berthelon

Valérie Guyard-Dangremont

Philippe Durbin

Gérard Ferrand

Nathalie Adje

Jean Jacques Berthelon

Trong Nghia Luong

Christoph Seyfried

Kai Schiemann

Timo Heinrich

Henning Bottcher

Henning Böttcher

Christoph Van Amsterdam

Didier Roche

Günter Hölzemann

Jean Jacques Zeiller

Ralf M Devant

Stéphane Yvon

Guy Augert

Fréderic Ausseil

Jean Berthelon

Jean-Jaques Berthelon

Jean-Jaques Zeiller

Guy Le Borgne

Compounds of the formula (1) in which R, R, X, Y and Z are as defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and the pharmaceutical compositions comprising them. 

Phenylbenzoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic uses thereof

The invention relates to compounds of the formula I: and to the pharmaceutically acceptable salts thereof, to processes for the preparation of them and to pharmaceutical compositions comprising them, which are useful especially for the treatment and prevention of dyslipidaemia, atherosclerosis and diabetes.

Substituted arylhexadienoic acids and esters thereof which can be used for the treatment and prevention of diabetes, dyslipidaemia and atherosclerosis, pharmaceutical compositions comprising them and processes for the preparation of them

Disclosed are Compounds of formula I  And methods of use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes.

Carboxylic acids and derivatives for the treatment of and preventing diabetes and dyslipidaemia

The invention concerns a benzodiazepin derivative of formula (I) and their use for treating dyslipidemia, atherosclerosis, diabetes and its complications.

Dihydrobenzodiazepins and their use for treating dyslipidemia

Benzodioxepines of the formula (I) and physiologically tolerated salts and solvates thereof, in which R, R, R, R, A, B, a and b have the meanings indicated in claim 1, are ligands of the 5HT1A receptors and/or the 5HT4 receptors with simultaneously strong serotonin reuptake inhibition. They can be employed for the treatment and prophylaxis of various diseases 

Substituted benzodioxepines

The present invention relates to benzopyrans and benzoxepines of formula (I), wherein X, A, R , R and (R) have the meanings as given in claim 1, which can be used in the treatment of dislipidaemias, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to processes allowing the preparation of these compounds.

Benzopyrans and benzoxepines, pharmaceutical compositions comprising them and preparation process

Amino(thio)ether derivatives of formula I ##STR1## wherein R.sup.0, R.sup.1, R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X and Z are as defined herein, and their salts, are active on the central nervous system.

Pyridyl chroman

The subject of the invention is compounds of general formula: ##STR1## in which: X represents O or CHR,

Benzocycloheptenes

Benzoxepines

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Toussieu, France

Michel Brunet