Sanofi

Elf Sanofi

Labaz

Michel Bouisset

Charles Pigerol

Alain Heymes

Claude Grain

Michel Chignac

Joel Radisson

Andre Bousquet

Raphael Sole

Michel Bonnery

Jean-Robert Dormoy

Alain Boudin

Christian Forqlly

The present invention relates to disodium 4-chlorophenylthiomethylenebisphosphonate monohydrate. The invention further relates to the method of preparing this monohydrate. The invention further relates to the pharmaceutical compositions in which disodium tiludronate monohydrate is present as the active principle.

Disodium 4-chlorophenylthiomethylenebisphosphonate monohydrate, its

The present invention relates to disodium 4-chlorophenylmethylenebisphosphonate monohydrate. The invention also relates to a method of preparing this form of the monohydrate, as well as to pharmaceutical compositions in which disodium tiludronate monohydrate is present as the active principle.

The subject of the invention is a process for the preparation of 4-methyl-2'-cyanobiphenyl of formula: ##STR1## wherein a benzonitrile halide of general formula: ##STR2## in which Hal represents a halogen atom, is reacted, in the presence of a manganese salt, with an organometallic derivative of general formula: ##STR3## in which X represents a halogen atom, and the complex obtained is then hydrolysed, which provides the desired compound.

Process for the preparation of a biphenyl derivative

Compounds of formula: ##STR1## in which R.sub.1 and R.sub.2 are hydrogen or halogen, are prepared by reacting an aldehyde of formula: ##STR2## with CHBr.sub.3 and KOH in a mixture of an inert solvent and water. Further an ester of compound (I) wherein R.sub.1 is H and R.sub.2 is 2-Cl is reacted with 4,5,6,7-tetrahydrothieno[3,2-c]pyridine to produce a compound of formula III: ##STR3## which is useful as a medicament.

Process for the preparation of phenylacetic derivatives of

The subject of the present invention is a process for the preparation of isoquinoline derivatives in four steps wherein use is made as synthetic intermediates of organo-lithium compounds or related compounds.

Process for the preparation of isoquinoline derivatives

The invention relates to the preparation of di-n-propylacetonitrile, according to a process consisting in heating N-(1-propyl-n-butyl)formamide to a temperature of between 350.degree. C. and 550.degree. C. and in the absence of oxygen, in the presence of a catalyst consisting of a silica impregnated with 0.1 to 10% by weight of alkali metal cations.

Process for preparing di-n-propylacetonitrile

Compounds of formula ##STR1## in which R.sub.1 and R.sub.2 are hydrogen or halogen, are prepared by reacting an aldehyde of formula: ##STR2## with CHBr.sub.3 and KOH in a mixture of an inert solvent and water. Further an ester of compound (I) wherein R.sub.1 is H and R.sub.2 is 2-Cl is reacted with 4,5,6,7-tetrahydrothieno[3,2-c]pyridine to produce a compound of formula III: ##STR3## which is useful as a medicament.

Process for the preparation of .alpha.-bromo-phenylacetic acids

Process for introducing a substituent selected from branched- or straight-chain alkyl radicals having from 1 to 12 carbon atoms, aralkyl or cycloalkyl radicals in which the alkyl moiety has from 1 to 4 carbon atoms, into a carbon chain bearing a stable functional group the said carbon chain having at least one proton in .alpha.-position in relation to this functional group, process whereby, in a first step, this carbon chain is reacted with a complex base comprising a mixture of alkali metal amide and alkali metal alcoholate suspended in an anhydrous organic solvent to provide temporarily a carbanion, then in a second step this carbanion is reacted in an anhydrous organic solvent with an alkyl, aralkyl or cycloalkyl halide corresponding to the substituent to be introduced.

Process for introducing alkyl radicals into carbon chains having a

The invention relates to 2-(4'-chloro-phenylthio)-benzonitrile, to its process of preparation and to its use for preparing 2-chlorothioxanthone. 2-Chloro-thioxanthone prepared from the compound of the invention is useful as a photoinitiator for the reticulation of synthetic resins and as an intermediate for preparing pharmaceuticals.

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Sisteron, France

Michel Bouisset