Fournier Industrie Et Sante

Laboratoires Fournier Sa

Laboratories Fournier S.a.

Inventiva

Michel Bondoux

Martine Barth

Pierre Dodey

Patrick Houziaux

Khan Ou

Didier Thomas

Véronique Barberousse

Christine Massardier

Jean-Michel Luccarini

Vincent Peyrou

Luc Lebreton

Christine Dumas

Jean-Luc Paquet

Didier Pruneau

The invention relates to novel 5-thioxylose compounds, preferably derivatives of the 5-thioxylopyranose type, to the process for their preparation and to their use as active principles of drugs intended especially for the treatment or prevention of thrombosis or cardiac insufficiency.

Compounds derived from 5-thioxylose and their use in therapeutics

The invention relates to new compounds of 5-thioxilose, preferably derivatives of the 5-thioxilopyranose type, and to a method for preparing the same and their use as the active ingredient of drugs mainly intended for treating or inhibiting thrombosis or heart failure or thromboembolic diseases.

Derivatives of 5-thioxylopyranose and use of same for treatment

Compounds of 5-thioxylopyranose, preferably derivatives of the 5-thioxilopyranose type, a method for preparing such compounds, and the use of such compounds as an active ingredient in pharmaceutical compositions which are useful, in particular, for treating or inhibiting thrombosis or heart failure or thromboembolic disease states.

5-thioxylopyranose compounds

5-thioxylose compounds, especially 5-thioxylopyranose compounds, a process for their preparation, and their use for treating and/or inhibiting thromboses, especially venous thromboses. The compounds correspond to formula I: in which the pentapyranosyl group represents a free or substituted 5-thio-&#x3b2;-D-xylopyranosyl group; R', R&#x2033; and R&#x2032;&#x2033; each independently represent a hydrogen atom, a C-Cacyl group, or two adjacent ones of them form a 1-methylethylidene bridge; Xand Xeach represent carbon or nitrogen; Yand Yeach independently represent carbon, nitrogen, sulfur or oxygen, with the proviso that if Yrepresents oxygen or sulfur, then Yrepresents carbon or nitrogen; R, R, R, Rand Reach independently represent hydrogen, a COORgroup where Rrepresents hydrogen or a C-Calkyl group optionally substituted by a phenyl ring, a halogen atom or a &#x2014;COORgroup; a C-Calkoxy group; a C-Cacyl group; a benzoyl group or a phenyl ring; and the addition salts and/or active metabolites of such compounds.

5-Thioxylopyranose compounds

The present invention concerns novel benzenesulphonamide compounds, defined by formula I. Therapeutic compositions comprising the benzenesulphonamide compounds of the invention or salts thereof and methods for producing the benzenesulphonamide compounds of the invention are also disclosed. The benzenesulphonamide compounds of the invention or salts thereof are useful for treating pain, such as hyperalgesia and major algesia.

Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain

Sulfonylindoline compounds of formula I, wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances, particularly for the treatment or inhibition of neurodegeneration, cardiovascular disease, inflammatory disease, hypercholesterolemia, dyslipidemia, obesity or diabetes.

Indoline compounds

The present invention relates to novel arylsulphonamide compounds, defined by formula I and the description, as well as their method of preparation and their therapeutic use 

Arylsulphonamide derivatives and methods of preparing

The invention concerns compounds selected among the group consisting of (i) compounds of formula (I) wherein: Het1 represents a nitrogenous heterocycle with 5 apices, in particular imidazole, pyrazole, or triazole; Het2 represents a nitrogenous heterocycle with 4, 5 or 6 apices, selected among the heterocycles: (II) wherein R and R are defined as mentioned in the description; and (ii) their additive salts. The invention also concerns the method for preparing said compounds and their use in therapy, in particular for treating pathologies involving bradykinine.

Growing community of inventors

Fontaine les Dijon, France

Michel Bondoux