Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Gencell, S.a.

Sorbonne Université

Universite Paris Cité

Ecole Nationale Superieure De Chimie De Paris

Michel Bessodes

Daniel Scherman

Serge Maitrejean

Nathalie Mignet

Didier Gourier

Corinne Chaneac

Jean-Pierre Jolivet

Quentin Le Masne De Chermont

Fabienne Sylvie Pelle

Christophe Masson

Barbara Wetzer

Yongmin Zhang

Didier Louis Gourier

Fabienne Julie Pelle

The invention relates to using persistent luminescence nanoparticles, functionalised if necessary, in the form of an diagnosis agent for an in vivo optical imaging. Said nanoparticles are preferably consist of a compound selected from a group comprising (1) silicates, aluminates, aluminosilicates, germanates, titanates, oxysulphides, phosphates and vanadates, wherein said compounds contain at least one type of metal oxide, (2) the sulphides comprise at least one metal ion selected from zinc, strontium and calcium, and (3) metal oxides, wherein said compounds is doped with at least one rare earth ion, and possibly with at least one transition metal ion. In a preferred embodiment, the diagnosis agent is used for an organism vascularization imaging. A method and kit for detecting or quantifying in vitro a substance of biological or chemical interest in a sample by using said pre-functionalised nanoparticles are also disclosed.

Persistent luminescence nanoparticles used in the form of a diagnosis agent for in vivo optical imaging

Novel acid-sensitive compounds comprising a cyclic ortho-ester that is acid-sensitive, and their salts, and comprising at least one hydrophilic substituent. These compounds are useful, for example, for forming conjugates (liposomes, complexes, nanoparticles and the like) with biologically active substances and releasing them into cellular tissues or compartments whose pH is acidic, or as nonionic surfactant for stabilizing particles encapsulating a biologically active substance and then destabilizing them in acid medium, or alternatively as a vector covalently linked to a therapeutic molecule so as to release said therapeutic molecule into the cellular tissues or compartments whose pH is acidic.

Acid-sensitive compounds, their preparation and uses

Growing community of inventors

Villejuif, France

Michel Bessodes