Wyeth

American Home Products Corporation

Michel Bernatchez

Sylvain Daigneault

Silvio Iera

Scott Mason Duncan

Augustine Tobi Osuma

Pierre Giguere

Graziano Castaldi

Giuseppe Barreca

Ronald Stanley Michalak

Vincenzo Cannata

The present invention provides a process for the preparation of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile comprising the steps and products disclosed within this application.

Process for the synthesis of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile

The invention claimed herein provides a process to oxidize N-(5-alkoxy-2-methyl-4-nitrophenyl)acetamides to N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids using potassium permanganate in the presence of magnesium sulfate in aqueous sulfolane or aqueous pyridine.

Process for the synthesis of N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids

Process for the synthesis of N-nacyl-2-amino-4-alkoxy-5-nitrobenzoic acids

This application discloses a process for producing 8-[2'-(2(1)-tert-butyl-2H-tetrazol-5-yl) -biphenyl-4-yl-methyl]-2,4-dimethyl-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin- 7-one (or such a compound wherein a benzyl or p-methoxybenzyl group is present in place of the tert-butyl group) or a salt thereof, said process characterized in

Chloro or bromo[2-[2-(tert-butyl)-2H-tetrazol-5-yl]phenyl]zinc

A process is described for preparing a compound of the formula I: ##STR1## or a salt thereof; wherein X is a protecting group and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen, C.sub.1-6 alkyl or C.sub.1-6 perfluoroalkyl, R.sub.5 is hydrogen or when n is 1 R.sub.5 taken together with R.sub.3 comprises a double bond; m is 1, 2 or 3; n is 0 or 1, and p is 0, 1 or 2.

Process for preparation of biphenyl derivatives

Growing community of inventors

Montreal, Canada

Michel Bernatchez