Strongbridge Dublin Limited

Strongbridge Ireland Limited

E-qure Corp.

Adb International Group Inc.

Michel Afargan

Elia Bernardino Ricci

Itshak Y Ben-Yesha

The present invention provides compositions comprising water soluble peptides with poor solubility in isotonic solutions which exhibit enhanced bioavailability with reduced adverse effects including injection site reactions. Methods are also disclosed for using such compositions for the treatment of diseases including, but not limited to, cancer, type 2 diabetes, acromegaly, metabolic disorders, endocrine disorders, exocrine tumors, and hormone-related tumors. Methods to reduce adverse injection site reactions and improve bioavailability are also disclosed.

Pharmaceutical compositions of water soluble peptides with poor solubility in isotonic conditions and methods for their use

A device for diagnosing a wound in a patient, the device comprising: at least two electrodes configured to be placed on the skin of the patient, wherein the at least two electrodes are placed in the vicinity of the wound; and at least one signal processor operatively coupled with the at least two electrodes, wherein the at least one signal processor is configured to: i) detect and record an endogenous alternating electrical signal in an area of the wound, ii) transform said endogenous alternating electrical signal into a voltage versus frequency spectrum using a Fast Fourier Transform (FFT) algorithm, and iii) diagnose the wound as a chronic wound if the voltage for a frequency between 65-200 Hz of the frequency spectrum is below 10&#xb1;10% volts and as an acute wound if the voltage for a frequency between 65-200 Hz of the frequency spectrum is above 10&#xb1;10% volts.

Wound diagnosis

Described herein are electrical markers, specifically alternate current (AC) signals whose appearance in patients with wounds, specifically chronic wounds, correlates to the prognosis of the wounds. Related methods that can be used for diagnosis and treatment of wounds are disclosed. Also described herein are methods that can be used to identify electrical signals of wounds.

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Raanana, Israel

Michel Afargan