Pfizer Corporation

Michel A Couturier

Derek Lawrence Tickner

Ernest S Hamanaka

Peter Bertinato

Ralph P Robinson

Marcus D Ewing

Peter Robert Rose

Frank R Busch

Harry O Tobiassen

Gregory J Withbroe

Susan L Orrill

Mark T Barrila

This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R&#x2014;R, X, m and n are as defined in the specification, as well as pharmaceutical compositions comprising the compounds, and methods of use of the compounds and compositions. The compounds of the invention are useful in treating obesity and associated diseases, conditions or disorders.

Substituted quinoline compounds

This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R-R, X, m and n are as defined in the specification, as well as pharmaceutical compositions comprising the compounds, and methods of use of the compounds and compositions. The compounds of the invention are useful in treating obesity and associated diseases, conditions or disorders.

Triamide-substituted heterobicyclic compounds

The instant invention provides novel processes and intermediates useful in the preparation of certain N-(indole-2-carbonyl)-&bgr;-alaninamide compounds, which compounds are glycogen phosphorylase inhibitors useful in the treatment of diseases such as hypercholesterolemia, hyperglycemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis, diabetes, diabetic cardiomyopathy, infection, tissue ischemia, myocardial ischemia, and in inhibiting tumor growth.

Processes and intermediates for preparing glycogen phosphorylase inhibitors

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Pawcatuck, CT, United States of America

Michel A Couturier