Achillion Pharmaceuticals, Inc.

Micheal John Pucci

Jason Allan Wiles

Milind Deshpande

Qiuping Wang

Barton James Bradbury

Edlaine Lucien

Ha Young Kim

Akhiro Hashimoto

Godwin Clarence Gilroy Pais

The invention provides compound and salts of Formula I and II, disclosed herein, which includes compounds of Formula A and Formula B: Such compounds possess useful antimicrobial activity. The variables R, R, R, R, R, and Rshown in Formula A and B are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.

8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents

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Kensington, CT, United States of America

Micheal John Pucci