The General Hospital Corporation

Michalina Gora

Guillermo J Tearney

Brett Eugene Bouma

Robert Carruth

Milen Stefanov Shishkov

Norman S Nishioka

Kevin Gallagher

Moon Gu Lee

Nima Tabatabaei

Jenny Sauk

Dongkyun Kang

Hongki Yoo

Melissa Suter

Dongyun Kang

An exemplary apparatus for obtaining data for at least one portion within at least one luminal or hollow sample can be provided. For example, the apparatus can include a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the portion(s). The apparatus can also include a wavelength dispersive second arrangement, which can be configured to disperse the electromagnetic radiation(s). A housing can be provided with a shape of a pill, and enclosing the first and second arrangements.

Apparatus, device and method for capsule microscopy

According to exemplary embodiments of the present disclosure, apparatus, device and method can be provided which can provide imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques in an automatic or semiautomatic manner. The exemplary apparatus, device and method can utilize a tethered capsule catheter with a mechanism for manual, semi-automatic or automatic traversing in the luminal organ with a controlled velocity and/or image quality. The exemplary apparatus can include feedback information about tension applied to the catheter during its movement that can be used to adjust velocity and assure patient comfort and safety for example during passing through natural sphincters and/or narrowing of the luminal organs and preventing from breaking of the catheter. The exemplary apparatus can also adjust velocity in order to provide good quality of acquired images, for example to engaged peristalsis and provide contact with the tissue. In one exemplary embodiment of the present disclosure, the exemplary mechanism for a controlled advancement of the catheter can be positioned outside of the patient's mouth, and can include a position sensor providing information about the position of the capsule in respect to the luminal organ for orientation of the acquired data.

System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device

In accordance with exemplary embodiments of the present disclosure, device and method can be provided which can facilitate imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques. The exemplary device can include different designs an features of one or more catheters, which can illuminate the tissues, and collect signals from the inside of the lumen. In another exemplary embodiment according to the present disclosure, a balloon-catheter can be provided with the flexible neck, which can absorb most of the bending. According to still another exemplary embodiments of the present disclosure, a balloon-catheter tethered capsule can be provided, and according a yet further exemplary embodiment, a structured balloon design can be provided with one or more protuberances, thus enabling imaging of the structures in close contact, e.g., without compressing of the tissue.

Apparatus and method for devices for imaging structures in or at one or more luminal organs

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Somerville, MA, United States of America

Michalina Gora