Zentiva K.s.

Michal Voslar

Ludek Ridvan

Ondrej Dammer

Tomas Pekarek

Monika Zatopkova

Stanislav Radl

Lukas Krejcik

Petr Hruby

Hana Brusova

Ales Halama

Pavel Zvatora

Michal Zapadlo

Lucie Krumbholcova

Ridvan Ludek

Zatopkova Monika

Pekarek Tomas

In the preparation of zolmitriptan of formula III the reduction of the diazonium salt to (5)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one of formula IV is performed in a more concentrated mixture and by the effect on an alkali metal disulphite, preferably sodium disulphite. A zolmitriptan toluene solvate, characterized by a toluene content of 9 to 14% by weight according to the gas chromatography determination and by a maximum of the corresponding mass loss at temperatures of about 111&#xb0; C. in the gravimetric analysis record. A zolmitriptan toluene solvate, showing strong Raman bands at the wave numbers of 1443 and 1354 cm1, characteristic for the crystal lattice of zolmitriptan with built-in toluene, and further marked bands at 1004 and 786 cm1, characteristic for toluene. 

Method for the preparation of zolmitriptan

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Praha, Czechia

Michal Voslar