Medimmune Limited

Michaela Wendeler

Alan Hunter

Timothy Pabst

Xiangyang Wang

Christopher D Thompson

Thomas Linke

Jihong Wang

Robert Strouse

Guoling Xi

Andrew Fulton

Kendall Carey

Johnson Varghese

Tim Pabst

Chris Thompson

The present invention provides methods of preparing active immunoconjugates, including anti-CD22 immunoconjugates. Suitably, the methods include a fed-batch refolding process and/or column stripping process that result in an increase in yield of the immunoconjugate over other processes that do not utilize the methods.

Methods of producing immunoconjugates

The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (Factor II). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin. Also provided are purified recombinant coagulation factor proteins.

Methods for processing coagulation factors

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Gaithersburg, MD, United States of America

Michaela Wendeler