Dritte Patentportfolio Beteiligungsgesellschaft Mbh &Co. Kg

Scandion Oncology A/s

Wolff Cellulosics Gmbh Co. Kg

Universitatsklinikum Jena

Collaborations Pharmaceuticals, Inc.

Makarov, Vadim

Michaela Schmidtke

Thomas Heinze

Sean Ekins

Hans-Martin Dahse

Peter Wutzler

Vadim Albertovich Makarov

Ute Möllmann

Albert Härtl

Vadim Albertovitch Makarov

Vera Haack

Vadim Makarov

The present invention relates to 5-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives of the general formula I or pharmaceutically acceptable salts or propharmacons thereof, wherein at least one hydrogen atom in at least one of the phenyl groups A and B is substituted by a substituent R, which has a Hammett constant &#x3c3;greater than 0.23. The present invention also concerns the method of its manufacture. For corresponding compounds, surprisingly a particularly high activity against viruses, in particular rhinoviruses and picornaviruses was determined. Furthermore, the compounds are tolerated very well. For these reasons the compounds are suitable for the treatment of viral infections and as drugs.

4-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives, their manufacture and their use as antiviral active substances

4-amino-3-arylamino-6-arylpyrazolo[3,4-d]pyrimidine derivatives of general formula (I), pharmaceutically acceptable salts thereof, method for preparation of the aforesaid compounds and their use as antiviral agents. 

4-amino-3-arylamino-6-arylpyrazolo[3,4-d) pyrimidine derivatives, methods for their preparation and their use as antiviral agents

The present invention relates to a method of treating infectious diseases, that involves: (a) providing an alpha-glycosidically linked starch polysaccharide derivative; and (b) inhibiting the growth of an infectious disease by administering a composition comprising the alpha-glycosidically linked starch polysaccharide derivative. The alpha-glycosidically linked starch polysaccharide derivative represented by the following general formula I, in which: the alpha-glycosidically linked starch polysaccharide derivative has a degree of quaternary ammonium group substitution of from 0.4 to 2.0; n is 2-4; Ris selected from the group consisting of Calkyl, benzyl and benzyl substituted with a member selected from the group consisting of Calkyl, halogen, alcoxy, carbamoyl, alkoxycarbonyl, cyano, dialkylamino and hydrogen; Rand Rare each independently selected from the group consisting of Calkyl, benzyl and benzyl substituted with a member selected from the group consisting of Calkyl, halogen, alcoxy, carbamoyl, alkoxycarbonyl, cyano and dialkylamino; and X is an anion selected from the group consisting of halide, hydroxide, sulfate, hydrogen sulfate and carboxylate.

Method of treating infectious diseases with polysaccharide derivatives

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Jena, Germany

Michaela Schmidtke