Other

Faro Technologies, Inc.

Columbia University

New York University

Spirent Communications, Inc.

Michael Y Shen

Paul Christopher Atwell

Kishore Lankalapalli

Keith George Macfarlane

Jacint R Barba

Nitesh Dhasmana

Christopher Michael Wilson

Jeremy W Mares

Jef D Boeke

Yazid Tohme

Andrea Califano

Christopher M Riehl

Kevin Canady

Richard Wank

Mike Ludwig

Yi Wu

Randy R Fields

Corinne Abate-Shen

Chee Wai Chua

Ming Lei

Provided are compositions and methods for making a diploid yeast having heterozygosity for at least one chromosome. The method includes mating haploid yeast having at least a first modified chromosome comprising a synthetic chromosome suitable for recombination-site-mediated evolution (as a SCRaMbLE-ready modification). The SCRaMbLE-ready modification includes introduced site-specific recombinase recognition sites that can be recognized by a recombinase. Yeast that have at least one SCRaMbLE-ready modification of a chromosome are mated with a haploid yeast devoid of the SCRaMbLE-ready modification to obtain diploid SCRaMbLE-ready yeast. Subsequent to mating the haploid SCRaMbLE-ready yeast to yeast devoid of the SCRaMbLE-ready modification the method includes using the recombinase to recombine the first modified chromosome to obtain heterozygous diploid yeast comprising at least one recombined (SCRaMbLEd) chromosome and a homologous non-SCRaMbLEd chromosome. The method further includes identifying heterozygous diploid yeast that comprise the at least one SCRaMbLEd chromosome that have a changed phenotype that is different from the phenotype of the diploid SCRaMbLE-ready yeast. Yeast made by the methods, compositions of matter made by the yeast, spores made by the yeast, and kits containing the yeast and/or their spores are included.

SCRaMbLE of heterozygous diploid yeast

A method includes providing a measuring device having a projector, a camera with a photosensitive array, and at least one processor, projecting with the projector a line of light onto an object, capturing with the camera an image of the projected line of light on the object within a window subregion of the photosensitive array, and calculating with the at least one processor three-dimensional (3D) coordinates of points on the object based at least in part on the projected line of light and on the captured image.

Photosensor processing for improved line scanner performance

A method includes providing a measuring device having a projector, a camera with a photosensitive array, and a processor, projecting with the projector a line of light onto an object, capturing with the camera an image of the projected line of light on the object within a window subregion of the photosensitive array, and calculating with the processor three-dimensional (3D) coordinates of points on the object based at least in part on the projected line of light and on the captured image.

A personalized acute care treatment kit is provided that includes components necessary for a lay caregiver to treat an acute cardiac event. The kit includes a medication box provided with medications selected according to the needs of the owner, a CPR device, a pacemaker, a defibrillator, monitoring and diagnostic devices and a computing device. The computing device is provided with a mobile application that captures patient data from the devices in the kit and automatically sends an alarm to a treatment professional when the patient data exceeds a predetermined threshold and establishes a communication link to with the treatment professional to allow the treatment professional to instruct the lay caregiver in using the contents of the kit to provide acute care.

Acute care eco system integrating customized devices of personalized care with networked population based management

A portable articulated arm coordinate measuring machine (AACMM) for measuring the coordinates of an object in space and a method of operating the AACMM is provided. The AACMM includes a laser line probe is having a projector and a camera, the projector projecting a line of light, the camera having a lens assembly and a sensor assembly. The sensor assembly having a filter disposed between a photosensitive array and the lens assembly. The filter has a plurality of red, green and blue pixels in a predetermined arrangement. A controller causes the camera to acquire a metrology image and a color image. 3D coordinates of points on a surface are determined based on the metrology image and a color is assigned to the points based on the color image. The exposure time for the color image is adjusted based on an Exposure To The Right or a Mid-gray color model.

Articulated arm coordinate measuring machine having a color laser line probe

An articulated arm coordinate measuring machine includes a laser line probe. The laser line probe includes a camera that can acquire metrology data and color data. A laser line probe is coupled to a probe end of an articulated arm. The laser line probe having a projector and a camera, the projector being operable to project a line of light at one or more predetermined wavelengths, the camera having a lens assembly optically coupled to a sensor assembly. The sensor assembly has a photosensitive array and a filter disposed between the photosensitive array and the lens assembly. The filter includes a plurality of red, green and blue pixels in a predetermined arrangement. A controller is coupled to the laser line probe and causes the camera to acquire a metrology image and a color image. The controller assigns a color to the three-dimensional coordinate points based on the color image.

Methods, pharmaceutical formulations and medicaments for treating prostate cancer or preventing the progression of a nonaggressive form of prostate cancer to an aggressive form, in a mammal, include a therapeutically effective amount of one or more active agents that reduce the expression or biological activity of both Forkhead box protein M1 (FOXM1) and Centromere protein F (CENPF) or biologically active fragments thereof or biologically active fragments thereof selected from the group consisting of an isolated shRNA, siRNA, antisense RNA, antisense DNA, Chimeric Antisense DNA/RNA, microRNA, and ribozymes that are sufficiently complementary to either a gene or an mRNA encoding either FOXM1 or CENPF proteins. A method is also presented for discovering synergistic master regulators of other phenotype transitions, wherein the master regulators are conserved among different species.

Method and composition for diagnosis or treatment of aggressive prostate cancer

The invention discloses a methodology for the culture of prostate tissue organoids from mouse and human prostate.

Method for culture of human and mouse prostate organoids and uses thereof

A unique method/device for isolating the over-the-air segment within a mobile communications network is provided. A coordinated set of tests is run to isolate problems in an end-to-end network including over-the-air segment, wired, and core network segments. Test results are compared to identify which segment or components within a segment is failing. The testing device executes the same test in two differentiated modes. In one mode, the device acts as a mobile client device identified by subscriber identification data that communicates with the network base station over-the-air using the standard control and data protocols of the mobile network. In another mode, the testing device, identified by the same subscriber identification data, acts like the combination of the same Mobile Client Device(s) and a Network Base Station using a wired interface that is equivalent to the wired interface that connects the network base station to the rest of the wired network.

Over-the-air isolation testing

A system and method for extracting medical information into a digital format; classifying the medical information into a database with customizable standard categories; and implementing the new information on all related customers' system in large scale networks.

Apparatus and method of automated information extraction and implementation through large scale networks

Managing information flow and workflow in medical imaging services includes mapping activities in medical imaging services to a set of discrete steps in a model medical imaging process. Data concerning the medical imaging services is collected and tracked using an electronic data store and a communications network. Collected data is correlated to at least one of the discrete steps in the model medical imaging process, and process metrics for performance are calculated based upon the correlated data.

Management of information flow and workflow in medical procedures

Managing information flow and workflow in medical imaging services includes mapping activities in medical imaging services to a set of discrete steps in a model medical imaging process. Data concerning the medical imaging services is collected and tracked using an electronic data store and a communications network. Collected data is correlated to at least one of the discrete steps in the model medical imaging process and process metrics for performance are calculated based upon the correlated data.

Growing community of inventors

Collingswood, NJ, United States of America

Michael Y Shen