Microdose Therapeutx, Inc.

Michael Xie

Sharon Shacham

Dilara McCauley

Vincent Jacques

Oren Becker

Ashis K Saha

Yael Marantz

Zhaoda Zhang

Pini Orbach

Efrat Ben-Zeev

A Sekar Reddy

Dilara Mccaulay

Provided are adenosine analog compounds such as that act as P2Y receptors, e.g., the P2Yreceptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer.

Adenosine analogs and their use

Provided are adenosine analog compounds of the general formula that act as P2Y receptors, e.g., the P2Yreceptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer. 

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Natick, MA, United States of America

Michael Xie