Merck Patent Gmbh

Merck Patent Gesellschaft MIT Beschrankter Haftung

Novartis Ag

Merck Patent Gesellschaft MIT Beschraenkter Haftung

Merck Patent Gesellschaft

Allgaier Werke Gmbh

Tetra Laval Holdings & Finance S.a.

Merck Patent Gesellschaft MIT Beschr&auml;nkter Haftung

Alcatel Sel Aktiengesellschaft

Michael Wolf

Hans-Michael Eggenweiler

Rochus Jonas

Norbert Beier

Michael Gassen

Hans-Peter Buchstaller

Pierre Schelling

Christian Sirrenberg

Michael Klockow

Franz-Werner Kluxen

Thomas Ehring

Thomas Welge

Joachim Leibrock

Fabian Kern

Ottmar Lehr

Roger Biel

Peter Hagmann

Günter Lässig

Hans-Jochen Schliep

Jonas Rochus

Peter König

Klaus Leinmüller

Dieter Waidmann

Christoph Seyfried

Bernhard Seiferling

Manfred Baumgarth

Bertram Cezanne

Axel Heinrich

Hans-Eckart Radunz

Markus Weigandt

Karl-August Ackermann

Andrea Hanefeld

Hartwig Steckel

Eberhard Sendobry

Matthias Schroeder

Werner Ludwig

Hans Peter Buchstaller

Peter Walden

Hans Michael Eggenweiler

Willy Kinzy

Regina Scherliess

Karsten B Sorensen

Wolfgang Beier

Christian Süppel-Adrian

Oliver Pöschke

Matthias Mihm

Thomas Richter

Alexander Müller

Michael Romer

Hans Armbruster

Rochust Jonas

Percy Knolle

Hanse-Michael Eggenweiler

Gerd-Albrecht Luckenbach

Andrea Diedrich

Renato Brito Baleeiro

Peter Konig

Klaus Leinmuller

A device for forming a sheet-metal blank, the device including: a press frame; a tool top part including an outer die and an inner die; a tool base part including a punch and a sheet-metal holder; at least one drive assigned to the tool top part and/or the tool base part; and an annular sheet-metal holder surrounding the punch and having a support face; wherein one drive is in each case assigned to the inner die on the one hand, and to the outer die and the sheet metal holder on the other hand, and the one drive displaces the inner die and the outer die at different speeds in the drawing direction. A method of forming a sheet-metal blank including: using the device during a starting period, an intermediate phase, and a final phase where the movement and/or direction of the two dies vary.

Device for forming a sheet-metal workpiece

The present invention is directed to nanoparticles comprising chitosan and an antigen, whereby the chitosan has a degree of deacetylation of about 90% and a molecular weight from 5 kDa to 80 kDa, to microparticles containing such nanoparticles as well as to a process for preparation of such particles. The particles are usable for vaccination.

Antigen-loaded chitosan nanoparticles for immunotherapy

The invention relates to a device for processing a workpiece, said device including the following features: a punch on one side of the workpiece, a die on the opposite side of the workpiece, and a conductive electric heating system for generating an electric current that flows through the workpiece starting from a component situated on one side of the workpiece outside of the punch to a component situated on the opposite side of the workpiece outside of the die.

Device for forming metals

The invention relates to an apparatus, an installation and a method for machining a workpiece made of metal, such as steel, by a machining processes such as forming, pressing, drawing, compressing and cutting. The invention includes at least two tools and a drive associated with the tools for their movement and for carrying out the machining process. The drives are arranged in such a way that when travelling on trajectories the tools have different speeds over at least a part of their trajectories.

Device and method for machining a workpiece consisting of metal, particularly for producing a cup-shaped component for the automobile industry, as well as such a workpiece

A gripper (1) for a contact lens (CL) includes a gripper head (10) having a bearing surface (11), the bearing surface (11) having at least one opening (110) through which underpressure can be applied in order to suck the contact lens (CL) against the bearing surface (11) and through which overpressure can be applied in order to release the contact lens (CL) from the bearing surface (11). The gripper further includes a detection opening (111) in the bearing surface (11) through which a separate underpressure can be applied.

Gripper for a contact lens and process for transporting a contact lens

5-[4-(2-Methylphenyl)-3-hydroxy-4H-1,2,4-triazol-5-yl]-2,4-dihydroxy-N-methyl-N-butylbenzamide is an HSP90 inhibitor and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

Triazole derivative as an HSP 90 inhibitor

A gripper () for a contact lens (CL) includes a gripper head () having a bearing surface (), the bearing surface () having at least one opening () through which underpressure can be applied in order to suck the contact lens (CL) against the bearing surface () and through which overpressure can be applied in order to release the contact lens (CL) from the bearing surface (). The gripper further includes a detection opening () in the bearing surface () through which a separate underpressure can be applied.

Novel indazole derivatives of the formula (I), in which R-Rhave the meanings indicated in Claim (), are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

Indazole derivatives for the treatment of HSP9O-induced diseases

Novel triazole derivatives of the formula (I), in which R-R, and Y have the meanings indicated in claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

Triazole derivatives

Novel triazole derivatives of the formula (I) in which R-Rand Y have the meanings indicated in Claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

Triazole derivatives II

The invention relates to novel thienopyridine derivatives of formula (I), wherein R1, R2, R3, R4 and Y have the meaning cited in claim, are HSP90-inhibitors and can be used for producing a medicament for treating illnesses, wherein the inhibition, regulation and/or modulation of HSP90 plays a roll. 

Thienopyridines

Novel adenine derivatives of the formula (I), in which R, R, R, X and Y have the meanings indicated in Claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

Adenine derivatives

Novel phenylquinazoline derivatives of the formula (I), in which R, R, R, Rand Rhave the meanings indicated in Claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

2-amino-4-phenylquinazoline derivatives and the use thereof as HSP90 modulators

Novel thienopyridine derivatives of the formula (I), in which R, R, Rand Y have the meanings indicated in claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

Thienopyridine derivatives and the use thereof as HSP90 modulators

Novel 1,5 diphenylpyrazole derivatives of the formula (I), in which R-Rhave the meanings indicated in Claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

1,5-diphenylpyrazoles

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Darmstadt, Germany

Michael Wolf