Mirabilis Medica, Inc.

University of California

Sensoriis, Inc.

Michael William Lau

Michael J Connolly

Shahram Vaezy

Alexander Lebedev

Michael P H Lau

Hung V Cao

Nelson Teng

Paul Marsh

The present invention features the application of a simple, inductively-coupled measurement system into the cap of standard laboratory sample tubes, thus enabling continuous, wireless ionic sensing of a bevy of samples. The system may be powered by a compact Class E amplifier using inductive coupling via a designed resonance frequency of 1 MHz. Other frequencies can be used, such as the popular near-field communication (NFC) frequency of 13.66 MHz. Signals are transmitted back via load modulation at frequencies a fraction of the power carrier frequency, thus allowing for extraction of the signal frequency. Results clearly show that modulation frequency tracks closely with open circuit potential, and the system features good sensitivity and linearity. This system holds promise for a host of applications.

Cloud-enabled passive wireless ionic sensing in small vials

A probe having a high intensity focused ultrasound (HIFU) transducer is positioned in a female patient. The HIFU transducer is deployed within the vagina of the patient outside of the cervix and uterine cavity and is configured to direct HIFU energy to a treatment site within the uterus of the patient. An imaging component positioned relative to the patient images a portion of the patient's uterus that includes the treatment site to help guide the delivery of the HIFU energy to the treatment site. A liquid medium may be infused into the uterine cavity of the patient where it is maintained during imaging and delivery of the HIFU therapy. The HIFU transducer produces a thermal heating of tissue at a focus within the treatment site to initiate necrosis of the tissue. The location of the focus is controlled in accordance with an image obtained by the imaging component.

Methods and apparatus for the treatment of menometrorrhagia, endometrial pathology, and cervical neoplasia using high intensity focused ultrasound energy

An apparatus for delivering HIFU energy may include a probe with a plurality of leaves that provide a bowl-shaped HIFU therapy transducer. In once case, pins may slide within grooves in the leaves to deploy the leaves. In another case, spines may be configured to slide in a channel defined in each leaf. In other cases, a spring or a shape memory alloy may be used to deploy the leaves. In another implementation, a probe may be fitted with a flexible material that couples the HIFU therapy transducer to the probe and allows the transducer to be drawn to the side of the probe for insertion. In another implementation, a probe may have one or more inflatable bladders that form the HIFU therapy transducer. In yet another implementation, a probe may have an imaging component and a HIFU therapy transducer disposed thereon that rotate, as a unit, about a hinge.

Apparatus for delivering high intensity focused ultrasound energy to a treatment site internal to a patient's body

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Edmonds, WA, United States of America

Michael William Lau