Curevac Ag

Curevac Manufacturing Gmbh

Curevac Real Estate Gmbh

Other

Curevac Se

Ludwig-Maximilians-Universitat München

Coriolis Pharmaservice Gmbh

Infap Gmbh

Michael Wiggenhorn

Thorsten Mutzke

Thomas Ketterer

Fabian Johannes Eber

Michael Sonntag

Katharina Kolland

Stefanie Sewing

Tilmann Roos

Benyamin Yazdan Panah

Florian Von Der Mülbe

Frank Schaubhut

Wolfgang Friess

Wenke Wagner

Markus Kreuz

Manfred Resch

Stefanie Sewig

The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

Dry powder composition comprising long-chain RNA

The present invention is directed to the field of RNA formulation, in particular to lyophilization of RNA. The invention provides a method for lyophilization of RNA. The present invention further concerns a lyophilized composition obtainable by the inventive method, a pharmaceutical composition, a vaccine and a kit or kit of parts. Moreover, the present invention provides a novel use of a lyoprotectant for lyophilizing RNA, the use of the inventive method in the manufacture of a medicament as well as the first and second medical use of the composition obtainable by the inventive method, the pharmaceutical composition, the vaccine or the kit or kit of parts according to the invention.

Lyophilization of RNA

The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

The present invention relates to a method for producing a liquid composition comprising a nanoparticle comprising at least one RNA and at least one cationic or polycationic compound, advantageously on a large scale suitable for pharmaceutical applications. The present invention further concerns the use of the inventive method in the manufacture of a medicament or a vaccine. Furthermore, the invention relates to compositions containing the RNA-comprising nanoparticle, and to pharmaceutical compositions comprising the same.

Method for producing RNA compositions

The invention provides a monitoring device () for a dryer () includes a means for sensing a physical parameter, such as temperature or strain, at a sensing locus within the dryer (), for example at a vial (). The sensing means comprises an optical sensing fiber () having at least one fiber Bragg grating (). Moreover, the invention provides a dryer, in particular a freeze dryer (), which is equipped with such monitoring device ().

Dryer with monitoring device

Growing community of inventors

Munich, Germany

Michael Wiggenhorn