University of Alberta

Alberta Health Services

Michael Weinfeld

Dennis Hall

Todd Randall Mereniuk

Edan Foley

Feridoun Karimi-Busheri

Gary Kenneth Freschauf

Dennis G Hall

Afsaneh Lavasanifar

Sylvain Bernard

Timothy Morgan

Vikie Lamontagne

James Z Xing

Zahra Shire

Xiao-Chun Le

Tristan Verdelet

There is described herein imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase.

Imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase

There is described herein compounds, compositions and methods for inducing synthetic lethality in a cancer cell(s).

Synthetic lethality in cancer

The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.

Small molecule inhibitors of polynucleotide kinase/phosphatase, poly(ADP-ribose) polymerase and uses thereof

The present invention provides methods for the detection and quantitation of any modification of interest in any nucleic acid sequence. In particular, the invention provides methods for detecting and quantitating low levels of modifications of interest in DNA sequences. The methods of the invention take advantage of combining the use of nucleic acid sequence modification-specific molecules which are specific for DNA modifications, of fluorescently labelled proteins which are specific for the nucleic acid sequence modification-specific molecules, of capillary electrophoresis and of laser-induced fluorescence. The methods of the invention are useful for identifying and detecting exposure to carcinogens, in early risk assessment for cancer, and in monitoring of cancer therapy.

Methods for quantitating low level modifications of nucleotide sequences

Growing community of inventors

Edmonton, Canada

Michael Weinfeld