Hoffmann-la Roche Inc.

Michael Weidner

Anja Limberg

Georg Fertig

Ralf Schumacher

Ulrike Reiff

Manfred Kubbies

Frank Herting

Tanja Ligensa

Gerd Zimmermann

Ulrike Leser-Reiff

Rainer Haag

Matthias Koerner

Mono-acylated o-phenylendiamines derivatives of formula A: which are useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.

Mono-acylated o-phenylendiamines derivatives

The invention relates generally to a method for the detection of the proliferation of a tumor cell and more specifically wherein said method comprises nucleic acids (SEQ ID NO:1) encoding IIP-1.

Methods for detecting cancer cells by using nucleic acid encoding for IGF-1 receptor interacting proteins

The invention comprises a nucleic acid molecule with the sequence SEQ ID NO:5 and the complementary sequence, and its use in diagnosis and therapy. This nucleic acid molecule (IIP-10) is a gene which encodes an IGF-1 receptor binding polypeptide.

IGF-1 receptor interacting proteins

Mono-acylated o-phenylendiamines derivatives of formula I wherein X and R are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.

N-monoacylated o-phenylenediamines

The invention comprises a method of screening compound(s) that inhibit the interaction between IGF-1R and IIP-10.

The present invention relates to compounds of formula I, their pharmaceutically acceptable salts as well as their enantiomeric forms, diastereoisomers and racemates; the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds as inhibitors of histone deacetylase (HDAC) and therefore in the control or prevention of illnesses and disorders as mentioned above, or in the manufacture of corresponding pharmaceutical compositions.

Oxime derivatives and their use as pharmaceutically active agents

The present invention describes compounds of the general formula I as well as processes for their manufacture, pharmaceutical compositions containing them and methods for using these compounds and pharmaceutical compositions as pharmaceutical agents. The compounds according to this invention show antiproliferative and differentiation-inducing activity, which results in inhibition of tumor cell proliferation, induction of apoptosis and inhibition of invasion.

Arylene-carboxylic acid (2-amino-phenyl)-amide derivatives

Mono-acylated o-phenylendiamines derivatives of formula A wherein Ar, R, and Rare as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.

New compounds represented by the formulaor pharmaceutically acceptable salts or prodrugs thereof,wherein

Growing community of inventors

Penzberg, Germany

Michael Weidner