University of Pittsburgh

The Brigham and Women's Hospital, Inc.

Brock University

Michael Wayne Epperly

Joel S Greenberger

Peter Wipf

Valerian Kagan

Melissa M Sprachman

Julie Pamela Goff

Julianne Glowacki

Jianfei Jiang

Xiang Gao

John S Lazo

Song Li

William D Bloomer

Jeffrey Atkinson

Hulya Bayir

Peter McDonald

Natalia A Belikova

Joshua Pierce

Abhay Sudhir Gokhale

Girish Ranadive

Jeffrey Stuart

Howard S Rosenzweig

Valarian E Kagan

Detcho A Stoyanovsky

Hülya Bayîr

Valerian E Kagan

Disclosed herein are embodiments of a method of accelerating bone healing in a subject in need thereof, comprising administering to the subject a compound disclosed here. The method may further comprise selecting or identifying a subject that has bone damage, or is a risk of developing bone damage. The compound may be administered after bone damage has occurred, or it may be administered prophylactically. The compound may be administered to a subject that has not and/or will not be exposed to radiation. In other embodiments, the subject has been and/or will be exposed to radiation.

Compounds for bone healing

A method of creating a formulation for a compound includes determining a compound interactive agent comprising at least one group that interacts with the compound, creating a carrier agent by conjugating at least one compound interactive domain comprising the at least one group that interacts with the compound with at least one hydrophilic domain, and combining the compound and the carrier agent to create the formulation. Creating the carrier agent may further include conjugating the at least one compound interactive domain with at least one hydrophobic domain so that the at least one compound interactive domain is positioned between the at least one hydrophilic domain and the at least one hydrophobic domain.

Formulations and carrier systems including compound interactive domains

Bifunctional compounds

The present application is directed to novel imidazole-substituted fatty acids that have been functionalized with an alkyl triphenylphosphonium group, compositions comprising these compounds and their use as inhibitors of cytochrome c peroxidase, in particular for the treatment and prevention of apoptosis.

Mitochondria-targeted inhibitors of cytochrome c peroxidase for protection from apoptosis

A compound having the formula: wherein X is S, SO or SO;one of R, R, and Ris O and the others of R, Rand Rare independently, the same or different, CH, or CRwherein, Ris an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or &#x2014;(CH)OR, wherein Ris an alkyl group or an aryl group and m is an integer in the range of 1 to 10, and one of R, R, and Ris O and the others of R, Rand Rare independently, the same or different, CH, or CRwherein, Ris an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or &#x2014;(CH)OR, wherein Ris an alkyl group or an aryl group and n is an integer in the range of 1 to 10;Rand Rare independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heteroaryl group, a C-Calkoxy group, an aryloxy group, or &#x2014;(CH)OR, wherein Ris an alkyl group or an aryl group and q is an integer in the range of 1 to 10, provided that Ris not a C-Calkoxy group or an aryloxy group when Ror Ris O and Ris not a C-Calkoxy group or an aryloxy group when Ror Ris O;R, R, Rand Rare independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, or an aryl group.

Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation or to mitigate apoptosis. The compounds comprise glyburide or other sulfonylurea hypoglycemic compounds or potassium channel inhibitors.

Radioprotective agents

Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

Use of targeted nitroxide agents in mitigating or treating radiation injury

Provided herein are compositions and related methods useful for accelerating bone healing and growth. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity.

Use of targeted nitroxide agents in bone healing

A method of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region, each region having an isoelectric point wherein said isoelectric point of the Fab fragment of said immunoglobulin is different than the isoelectric point of the Fc fragment of the immunoglobulin, said method comprising modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.

Regioselective chemical modification of monoclonal antibodies

Growing community of inventors

Pittsburgh, PA, United States of America

Michael Wayne Epperly