Boehringer Ingelheim Pharma Gmbh & Co Kg

Boehringer Ingelheim Pharma Kg

Boehringer Ingelheim International Gmbh

Michael Walz

Georg Boeck

Michael Trunk

Hagen Graebner

Helmut Bender

Konrad Schindler

Dieter Hochrainer

Karoline Bechtold-Peters

Christoph Kreher

Mareke Hartig

Norbert Rasenack

Rolf Doerr

Michael Josef Friedrich Trunk

Michael Josef Trunk

Rolf Dorr

Georg Bock

Stephanie Ossadnik

Nobert Rasenack

The invention relates to a method for producing a micronized, virtually anhydrous form of (1&#x3b1;,2&#x3b2;,4&#x3b2;,5&#x3b1;,7&#x3b2;)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide, said form per se, and the use thereof for producing a medicament, especially a medicament having an anticholinergic effect.

Micronization method

Disclosed is an inhaler, especially a powder inhaler, for administering a medicament in the form of inhalable substances, substance formulations, or substance mixtures. Said inhaler comprises a housing that is provided with a chamber () for accommodating the substances. The chamber () is replaceably disposed inside the housing.

Inhaler

The invention relates to powdered preparations containing tiotropium for inhalation, processes for preparing them as well as their use in preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.

Encapsulated tiotropium containing powder formulation for inhalation

Tiotropium containing powder formulation for inhalation

The invention relates to a crystalline micronisate of (1 &#x3b1;,2&#x3b2;,4&#x3b2;,5&#x3b1;,7&#x3b2;)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane-bromide, processes for preparing it and its use for preparing a pharmaceutical composition, particularly for preparing a pharmaceutical composition with an anticholinergic activity.

Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament

The invention relates to a crystalline micronisate of (1&#x3b1;,2&#x3b2;,4&#x3b2;,5&#x3b1;,7&#x3b2;)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane-bromide, processes for preparing it and its use for preparing a pharmaceutical composition, particularly for preparing a pharmaceutical composition with an anticholinergic activity.

The invention relates to a new process for producing powdered preparations for inhalation comprising a substance having a smaller particle size distribution and a substance having a larger particle size distribution, wherein a substance having a smaller particle size distribution and a substance having a larger particle size distribution are continuously metered into a suitable mixing container such that the quotient N of the delivery speed for the metering of the substance having the smaller particle size distribution and the delivery speed for the metering of the substance having the larger particle size distribution is at least as great as the quotient M of the total mass of the substance having the smaller particle size distribution and the total mass of the substance having the larger particle size distribution.

Process for preparing inhalable powders

Inhalable powder containing tiotropium

The invention relates to a new process for producing powdered preparations for inhalation.

Process for preparing powder formulations

The invention relates to a new process for producing powdered preparations for inhalation wherein a substance having a smaller particle size distribution is metered continuously through a suitable feed device onto a moving bed of a powdered substance having a larger particle size distribution.

Growing community of inventors

Bingen, Germany

Michael Walz