Other

Iogenetics, LLC

North Carolina State University

The University of Arizona

Arizona Board of Regents, a Body Corporate

Michael W Riggs

Lance E Perryman

Jane Homan

Michael Imboden

Deborah A Schaefer

Travis C McGuire

Douglas P Jasmer

Robert D Bremel

Stephane Carryn

The present invention relates to fusion proteins comprising a microorganism targeting molecule (e.g., immunoglobulin) and a biocide. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in diverse fields.

Targeted cryptosporidium biocides

The present invention relates to the use of biocide (e.g., bactericidal enzyme) to target pathogens. In particular, the present invention provides biocides for use in health care (e.g., human and veterinary), agriculture (e.g., animal and plant production), and food processing (e.g., water purification).

Biocides

DNA sequences encoding epitopes to which sporozoite-neutralizing antibodies are directed are provided. Recombinant proteins and synthetic peptides containing epitopes for inducing an antigenic response are described.

Neutralization-sensitive epitopes of Cryptosporidium parvum

Compositions and methods useful for conferring passive or active immunity to the parasite, . A high molecular weight glycoprotein antigen isolated from , capable of binding the mAb 3E2, was shown to harbor an epitope critical for triggering the neutralizing CSP-like reaction in the parasite. Antibodies targeted against the critical epitope were shown to possess neutralizing activity, and could be combined with other anti- monoclonal antibodies and administered to an animal to confer passive immunity. Immunogenic compositions including the purified antigen are disclosed for use in stimulating an active immune response against

Anti-cryptosporidium parvum preparations

DNA sequences encoding epitopes to which sporozoite-neutralizing antibodies are directed are provided. Recombinant proteins and synthetic peptides containing,epitopes for inducing, an antigenic response are described.

Compositions and methods useful for conferring passive or active immunity to the parasite, C. parvum. A high molecular weight glycoprotein antigen isolated from C. parvum, capable of binding the mAb 3E2, was shown to harbor an epitope critical for triggering the neutralizing CSP-like reaction in the parasite. Antibodies targeted against the critical epitope were shown to possess neutralizing activity, and could be combined with other anti-C. parvum monoclonal antibodies and administered to an animal to confer passive immunity. Immunogenic compositions including the purified antigen are disclosed for use in stimulating an active immune response against C. parvum.

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Tucson, AZ, United States of America

Michael W Riggs