Baylor College of Medicine

Beijing University of Technology

Peptides International, Inc.

La Trobe University

University of Massachusetts

Monash University

Michael W Pennington

Peter A Rice

Sunita Gulati

Brian John Smith

Sanjay Ram

Christine Beeton

Raymond S Norton

Jutamas Shaughnessy

Shih Chieh Chang

Serdar Kuyucak

M Harunur Rashid

Novel analogues of the sea anemonetoxin ShK, and their use as, for example, therapeutic agents for treating autoimmune diseases are disclosed. The analogues comprise a ShK toxin polypeptide and an N-terminal extension comprising an amino acid sequence according to formula (I): wherein Xis D, E or other negatively-charged amino acid or derivative thereof, Xis E, I, L, S, V, W or a tryptophan derivative, Xis any amino acid, Xis any amino acid, a is absent or a first additional moiety, and b is absent or a second additional moiety.a-XXXX-b(SEQ ID NO: 3)&#x2003;&#x2003;(I)

Potassium channel blockers and use thereof in the treatment of autoimmune diseases

A novel peptide analogue of thetoxin HsTX1 is disclosed along with its application as, for example, a therapeutic agent for treating an autoimmune disease such as multiple sclerosis (MS) or rheumatoid arthritis (RA). The analogue comprises a peptide with an amino acid substitution at amino acid position 14 of the wild-type (WT) peptide sequence (or a position corresponding to position 14 of the WT peptide sequence). The analogue exhibits selectivity for Kv1.3 over Kv1.1 and other potassium channels relative to the WT peptide.

Scorpion toxin analogue and method for treating autoimmune diseases

Growing community of inventors

Shelbyville, KY, United States of America

Michael W Pennington