Nutrition 21, Inc.

Ambi Inc.

Michael W Climo

Gordon L Archer

Ellen Murphy

Beth P Goldstein

Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans ofcell walls such as lysostaphin and an antibiotic effective againstdue to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, eventhat may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include &#x3b2;-lactams and glycopeptides.

Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains

Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective against staphylococci due to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, even staphylococci that may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include &#x3b2;-lactams and glycopeptides.

Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective against staphylococci due to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, even staphylococci that may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include &bgr;-lactams and glycopeptides.

Lysostaphin is an effective antibiotic in the treatment of staphylococcal infection. Large doses of lysostaphin or lysostaphin analogues are effective in short course, or even one dose administrations, in treating and eradicating staphylococcal infections, including those resistant to conventional antibiotics.

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Richmond, VA, United States of America

Michael W Climo