Laboratorios Cusi, S.a.

Michael Van Bergamini

Jose Alberto Vallet Mas

Francisco Javier Galan Valdivia

Jordi Coll Colomer

Ricardo Notivol Paino

Antonio L Cabrera

Carmen Oros Laguens

Teresa Borras Sanjurjo

Gemma T Cabello

It comprises: (1) preparing an aqueous phase containing surface active suspensor agents and, optionally, a chemically or biologically active chemical substance; (2) preparing an organic phase containing a biocompatible polymer or monomer and, optionally, a lipid or chemically or biologically active chemical substance; (3) mixing both phases in a continuous manner in a constant average phase-volume ratio, continuously removing a recently formed colloidal suspension; (4) continuously eliminating the solvent from the colloidal suspension; and (5) completely eliminating the organic solvent and part or all of the water in order to obtain the desired concentration of nanospheres or dry product. Application in biomedicine, pharmacy, medicine, cosmetics, chemical industry, agriculture, veterinary science, etc.

Process of continuous preparation of disperse colloidal systems in the

It comprises: 0.005-1.0% of trimethoprim or a pharmaceutically acceptable salt thereof: 0.01-0.3% of polymyxin or a pharmaceutically acceptable salt thereof: 0.001-5% of a steroidal or non-steroidal anti-inflammatory drug and, optionally, one or more ingredients selected from among isotonizing agents, pH buffers, viscosity modifying agents, wetting agents, chelating agents, anti-oxidants, preservatives and vehicles. The formulation has a pH between 4 and 8.5. It is applicable in the treatment of ophthalmic and otic infections accompanied by inflammation.

Pharmaceutical formulation comprised of polymyxintrimethoprim and an

This invention includes a pharmaceutically acceptable formulation of Diclofenac, Tobramycin, a solubility agent and, optionally, excipients, tonicifiers, buffers, viscosity modifying agents, preservatives, and chelating agents, at a pH from greater than 7.0 to about 9. The invention also discloses the use of this pharmaceutically acceptable formulation of an antibiotic and NSAIDs to treat eye and ear conditions accompanied by infection and inflammation.

Diclofenac and tobramycin formulations for ophthalmic and otic topicaluse

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El Masnou, Spain

Michael Van Bergamini