Arcturus Therapeutics, Inc.

Marina Biotech, Inc.

Michael V Templin

Michael E Houston, Jr

Pierrot Harvie

Roger C Adami

Narendra Vaish

Shaguna Seth

Kathy L Fosnaugh

Rachel E Johns

Barry A Polisky

Jaya S Giyanani

This invention provides single-stranded and multi-stranded compounds that are useful in various therapeutic modalities to regulate the expression of nucleic acid molecules in a cell. A range of compounds is provided, each containing one or more conformationally restricted nucleomonomers (CRN). In addition, compounds can contain one or more conformationally restricted nucleomonomers and one or more hydroxymethyl substituted nucleomonomers (unlocked nucleomonomers, UNA).

Therapeutics with conformationally restricted monomers

This disclosure provides double-stranded RNA complexes having one or more hydroxymethyl substituted nucleomonomer(s) in the passenger strand (or sense strand) of an RNA complex. RNA complexes of the disclosure may be useful for therapeutic applications, diagnostic applications or research applications. RNA complexes include short interfering RNA complexes (siRNA) capable of modulating gene expression comprising an antisense strand and a continuous or a discontinuous passenger strand ('sense strand'). Further, one or more hydroxymethyl substituted nucleomonomer(s) of this disclosure may be positioned at the 3'-end, at the 5&#x2032;-end, at both the 3&#x2032;-end and 5&#x2032;end.

UNA oligomer structures for therapeutic agents

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Bothell, WA, United States of America

Michael V Templin