Mesoscale Technologies, Llc.

Other

Michael Tsionsky

George B Sigal

Eli N Glezer

Sudeep Kumar

Jonathan K Leland

Mark T Martin

Mark A Billadeau

Pankaj Oberoi

Larry Helms

Svetlana Leytner

Bandele J Jeffrey-Coker

Jeff D Debad

Gisbert Spieles

Selen Altunata

Michael Warnock

Jacob N Wohlstadter

John H Kenten

Niranjan Y Sardesai

James L Wilbur

Hans Biebuyck

Kent Johnson

Jeffery D Debad

Robert M Umek

Selen Stromgren

Paula Denney Eason

The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.

Reagent storage in an assay device

The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

Methods for conducting multiplexed assays

We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.

Assay modules having assay reagents and methods of making and using same

The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.

Kits suitable for use in electrochemiluminescence methods and methods of effecting a specific-binding non-wash assay

Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

Methods and apparatus for conducting multiple measurements on a sample

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Derwood, MD, United States of America

Michael Tsionsky