Flagship Pioneering Innovations V, Inc.

Children's Medical Center Corporation

Michael Travis Mee

Geoffrey Von Maltzahn

Jacob Rosenblum Rubens

John Miles Milwid

Kyle Marvin Trudeau

Kiana Mahdaviani

James D McCully

Douglas B Cowan

Neal Gordon

David Chess

Jacob Feala

Bo Zhang

Molly Krisann Gibson

Nathan Wilson Stebbins

Jagesh Vijaykumar Shah

Brigham Jay Hartley

Tamar Rose Putiri

Matthew Milnes Dobbin

The present disclosure provides, at least in part, methods and compositions for in vivo fusosome delivery. In some embodiments, the fusosome comprises a combination of elements that promote specificity for target cells, e.g., one or more of a fusogen, a positive target cell-specific regulatory element, and a non-target cell-specific regulatory element. In some embodiments, the fusosome comprises one or more modifications that decrease an immune response against the fusosome.

Fusosome compositions and uses thereof

Therapeutic chondrisome and mitoplast compositions and related methods are described.

Methods and compositions relating to chondrisomes from blood products

Therapeutic chondrisome compositions and related methods are described.

Methods and compositions relating to chondrisomes from cultured cells

In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.

Compositions for facilitating membrane fusion and uses thereof

Growing community of inventors

Montreal, Canada

Michael Travis Mee