Genentech, Inc.

Synaptics Corporation

University of London

F. Hoffmann-la Roche Ag

Nelson Irrigation Corporation

Michael Townsend

Craig B Nelson

Tracy Staton

Flavius Martin

Richard Hodges

Harry Lau

Alvernia Francesca Setiadi

Glynn Dennis, Jr

Alexander Abbas

Barmak Modrek

Jason A Hackney

Timothy W Behrens

Costantino Pitzalis

Kasia Owczarczyk

Myles Lewis

Nandhini Ramamoorthi

The present invention provides prognostic, predictive, and therapeutic methods for the treatment of rheumatoid arthritis (RA). The invention is based, at least in part, on the discovery that the expression level of one or more biomarkers described herein in a sample (e.g., a synovial tissue sample, a synovial fluid sample, or a combination thereof) from an individual having RA can be used in methods of determining whether an individual having RA is likely to exhibit disease progression, identifying an individual having RA who is likely to respond to a treatment including a disease modifying anti-rheumatic drug (DMARD), predicting responsiveness of an individual having RA to a treatment including a DMARD, selecting a therapy for an individual having RA, and treating an individual having RA, as well as related kits.

Diagnostic and therapeutic methods for the treatment of rheumatoid arthritis (RA)

The present invention concerns markers of multiple sclerosis, their use, and treatment with IL-17 antagonists, including IL-17 antibodies, of subjects with increased levels of such markers.

Gene expression markers and treatment of multiple sclerosis

Systems and methods for protecting a loudspeaker from excessive excursion include an audio source, an adaptive excursion protection filter, an audio clipper, an inverse excursion protection filter, an amplifier and a loudspeaker. The system performs operations including receiving an audio signal, applying an excursion protection filter, the excursion protection filter adapting in real-time to one or more speaker conditions, clipping the audio signal, applying an inverse excursion protection filter, and amplifying, using an amplification circuit, the audio signal for output to the speaker.

Protection of speaker from excess excursion

Biological markers that predict patient responsiveness to B-cell antagonists are provided. Also provided are methods of using such biological markers. In addition, methods for identifying patients suffering from an autoimmune disease, e.g., rheumatoid arthritis, who are not likely to respond to B-cell antagonists are provided, as are methods of treating such patients. Methods for selecting therapeutic agents to treat such patients are also provided.

Biological markers and methods for predicting response to B-cell antagonists

Methods of identifying, diagnosing, and prognosing rheumatoid arthritis are provided, as well as methods of treating rheumatoid arthritis. Also provided are methods for identifying effective rheumatoid arthritis therapeutic agents and predicting responsiveness to rheumatoid arthritis therapeutic agents.

Methods for treating, diagnosing, and monitoring rheumatoid arthritis

Interface for a keypad, keyboard, or user activated components thereof

This invention provides methods and compositions useful for detecting autoimmune disorders.

Methods for diagnosing and treating systemic lupus erythematosus

Interface for an alphanumeric user activated component, keypad, or keyboard

The invention provides methods and compositions useful for detecting autoimmune disorders.

Methods for detecting and treating systemic lupus erythematous

User interface for a keyboard, keypad, or touchscreen

Alphanumeric input keyboard

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San Jose, CA, United States of America

Michael Townsend