University System of Maryland

Scientific Industries, Inc.

Michael Tolosa

Govind Rao

Yordan Kostov

Douglas J Koebler

Joseph G Cremonese

Brookman P March

William Chandler

Leah Tolosa

Xudong Ge

Chandrasekhar Gurramkonda

David Burgenson

Leah Tolosa Croucher

Kevin Tran

Monohar Pilli

Manohar Pilli

Chandrashekar Gurramkonda

Vikash Kumar

Vida Rahmatnejad

A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The parent's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.

Microscale bioprocessing system and method for protein manufacturing from human blood

Embodiments of a cell culture monitoring system are disclosed that may include a device having collimating and filtering components to elicit and detect fluorescence from a substrate located within a reaction vessel. The device may be used to detect changes in pH and dissolved oxygen levels in a liquid contained in the reaction vessel due to growth of living cells. Excitation light beams can be generated and collimated by a beam combiner and directed into the reaction vessel so as to be incident upon the substrate to cause the substrate to fluoresce. Some embodiments include use of expected wavelength offsets and shifted filters/mirrors to improve functionality and reduce space of device components.

Apparatus for detecting pH and dissolved oxygen

Systems and methods for determining an in vivo concentration of a small molecule substance of interest is provided that takes advantage of the semi-permeable nature of skin, which allows small molecules to passively diffuse through the skin and onto the skin surface. The systems and methods of the present invention allow for the collection of these small molecules that have passively diffused through the skin without skin disruption or breaking of the skin. The systems and methods of the present invention are noninvasive, painless and safe even for delicate newborns, and are particularly suited for the determination of blood glucose in newborns and infants in a noninvasive manner.

System and method for determining an in vivo concentration of a small molecule substance of interest in a noninvasive manner

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Columbia, MD, United States of America

Michael Tolosa