Como Biotech Aps

Other

Mayo Foundation for Medical Education and Research

Como Holdings Aps

Como Holding Aps

Michael Toft Overgaard

Claus Oxvig

Cheryl A Conover

Gert Godvig Lassen

Jesper Ostergaard Kristensen

The present invention provides pregnancy associated plasma protein A2 (PAPP-A2), its nucleotide and amino acid sequences, antisense molecules to the nucleotide sequences which encode PAPP-A2, expression vectors for the production of purified PAPP-A2, antibodies capable of binding specifically to PAPP-A2, hybridization probes or oligonucleotides for the detection of PAPP-A2-encoding nucleotide sequences, genetically engineered host cells for the expression of PAPP-A2, and methods for screening for pathologies in pregnant and non-pregnant patients. Methods for screening for altered focal proliferation states in pregnant and/or non-pregnant patients, which include detecting levels of PAPP-A2, are also described.

Pregnancy-associated plasma protein-A2 (PAPP-A2) polypeptides

Pregnancy-associated plasma protein-A2 (PAPP-A2) polynucleotides

A telescopic lifting column for height adjustment of elevatable tables () consists of a stationary rectangular profile (), which at the bottom rests against a floor, and of a sliding quadrangular profile (), which slides inside the stationary profile () and which can be activated up or down by a linear actuator () and which at the top rests against a table top (). The profiles () each have an open side (resp.and), and the linear actuator is embodied as a toothed rack (), which is fastened to the internal side (') of the sliding profile () opposite the open side (), and which is in mesh with a toothed wheel (), which is coupled to a gear motor (), which is fastened to the stationary profile () of the lifting column. On the side facing the open side (), the toothed rack () is embodied with a guide way () with a width (a) in which two guide pins ()&#x2014;with a mutual distance (b) and fastened to the stationary profile ()&#x2014;are in mesh.

Telescopic lifting column for height adjustment of elevatable tables

Methods for screening for altered focal proliferation states in non-pregnant patients, which include detecting levels of pregnancy-associated plasma protein-A (PAPP-A) are described. Methods for identifying agents that alter the protease activity of PAPP-A, and pharmaceutical compositions and medical devices that include such agents are also described.

Method for detecting IGFBP-4 protease without detecting IGFBP-4 protease/proMBP Complex

The present invention provides nucleotide and amino acid sequences that identify and encode a new protein with homology to pregnancy-associated plasma protein-A (PAPP-A). We denote this protein PAPP-A2. The cDNA encoding PAPP-A2 was derived from human placenta. The present invention also provides for antisense molecules to the nucleotide sequences which encode PAPP-A2, expression vectors for the production of purified PAPP-A2, antibodies capable of binding specifically to PAPP-A2, hybridization probes or oligonucleotides for the detection of PAPP-A2-encoding nucleotide sequences, genetically engineered host cells for the expression of PAPP-A2, use of the protein to produce antibodies capable of binding specifically to the protein, methods for screening for pathologies in pregnant and non-pregnant patients that are based on detection of PAPP-A2 antigen in human body fluids or PAPP-A2-encoding nucleic acid molecules, use of the protein to screen for agents that alter the protease activity of PAPP-A2, use of the protein as a therapeutic target for such agents, and use of the protein as a therapeutic agent in relevant pathological states. Methods for screening for altered focal proliferation states in pregnant and/or non-pregnant patients, which include detecting levels of PAPP-A2, are also described. The present invention also provides the identification of a natural substrate of PAPP-A2, insulin-like growth factor binding protein (IGFBP)-5.

Growing community of inventors

Aarhus C, Denmark

Michael Toft Overgaard