Vertex Pharmaceuticals, Inc.

Pulmatrix Operating Company, Inc.

Pulmatric Operating Company, Inc.

Michael Tauber

Jean C Sung

Wesley H DeHaan

Diana Manzanedo

Ciaran Lawlor

Patrick Raymond Connelly

Sherry Collier

The invention related to dry powders that contain a therapeutic agent. The dry powders have characteristics, e.g., they are processable and/or dense in therapeutic agent that provide advantages for formulating and delivering therapeutics agents to patients.

Inhalable dry powders

The invention related to dry powders that contain a therapeutic agent. The dry powders have characteristics, e.g., they are processable and/or dense in therapeutic agent that provide advantages for formulating and delivering therapeutic agents to patients.

Methods for producing respirable dry powders

The invention relates to compositions and co-crystals each comprising (1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-1-carboxamide having the structure: and the co-crystal former 4-amino salicylic acid. Also within the scope of this invention are methods of making and using the same.

Co-crystals and pharmaceutical compositions comprising the same

The invention relates to compositions and co-crystals each comprising (1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-1-carboxamide having the structure: and the co-crystal former salicylic acid. Also within the scope of this invention are methods of making and using the same.

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Allston, MA, United States of America

Michael Tauber