Cargill Inc.

Michael Tai Man Louie

Hans H Liao

Travis Robert Wolter

Eileen Spindler

Michael David Lynch

Wendy Kathleen Ribble

Christopher Patrick Mercogliano

Tanya Lipscomb

Ana Negrete-Raymond

Erin Kathleen Marasco

Catherine B Poor

Michael D Lynch

Tanya E W Lipscomb

Ron Evans

Matthew Lipscomb

Brittany Robinson

Shelley Copley

Tanya Lipscomb-Warnecke

David Hogsett

Chrisopher Patrick Mercogliano

Eileen Colie Spindler

Tanya Lipscomp

This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a fatty acid or fatty acid derived product, wherein the modified microorganism produces fatty acyl-CoA intermediates via a malonyl-CoA dependent but malonyl-ACP independent mechanism.

Microorganisms and methods for the production of fatty acids and fatty acid derived products

Genes encoding mutant 3-ketoacyl-CoA synthases are introduced into host cells. Certain of the mutants enhance the production of shorter-chain fatty acids and derivatives by the cell than do the wild-type (unmutated) enzymes. In other cases, the chain length is not significantly affected, but productivity is enhanced. In specific cases, both a shift toward lower chain length and higher productivity is seen. Cells producing the mutant 3-ketoacyl-CoA synthases are especially suitable for producing C6-C10 fatty acids and derivatives.

Genetically modified cells that produce C6-C10 fatty acid derivatives

The present invention provides various combinations of genetic modifications to a transformed host cell that provide increase conversion of carbon to a chemical product. The present invention also provides methods of fermentation and methods of making various chemical products.

Acetyl-CoA carboxylases

Bioproduction of chemicals

Acetyl-coA carboxylases

Growing community of inventors

Broomfield, CO, United States of America

Michael Tai Man Louie