Gilead Sciences, Inc.

Michael T Tudesco

Chandrasekar Venkataramani

Peter A Blomgren

Musong Kim

Zhimin Du

Rhiannon Thomas-Tran

William John Watkins

Suet Chung Yeung

Julian Andrew Codelli

Gayatri Balan

Gregg M Schwarzwalder

Helen Yu

Chen Chen

Dorothée Saddier Axe

Brian M Weist

The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

IKAROS Zinc Finger Family degraders and uses thereof

The present disclosure relates to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2, including cancer.

IKAROS zinc finger family degraders and uses thereof

Growing community of inventors

Chapel Hill, NC, United States of America

Michael T Tudesco