Coopers Animal Health Limited

Coopers Animal Health Australia Limited

Michael T Shepherd

Rodney C Baker

Clifford A Graham

Peter H Marsden

Scott Edwards

An intraruminal device for controlled release of a drug formulation in the rumen of an animal, comprises an open-ended tube for containing the drug formulation, a piston adapted to travel longitudinally within the tube and biased so as to deliver the drug formulation through the open end of the tube. Travelling with the piston is an associated weight adapted to retain the device within the rumen during delivery of the drug formulation.

Intra-ruminal device for delivering drugs

A bolus for releasing a biologically active substance into a liquid environment according to this invention comprising an elongate core, at least one end of which is frustoconical and a liquid impervious casing at one end and open at the other disposed about the core, the bolus being so constructed that, in use, the casing is progressively shed as the core retreats, thereby releasing the active substance at a rate which varies over at least one time period, the casing being so structured as to retain its integrity without disintegrating in the absence of any support provided by the core.

Bolus for releasing a biologically active substance into a liquid

A heavy density depot for lodgement in the remeno-reticulum of a ruminant animal and progressive release of veterinary substance, comprises an elongate body containing the veterinary substance and having an aperture to allow its progressive release, and a domed weight at a leading end of the body to facilitate passage down the animal's oesophagus. The weight is usually outside the body. The construction is particularly compact so maximizing the amount of veterinary substance contained.

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Berkhamsted, United Kingdom

Michael T Shepherd