Leland Stanford Junior University

Neodyne Biosciences, Inc.

Michael T Longaker

Geoffrey C Gurtner

Reinhold H Dauskardt

Paul G Yock

John A Zepeda

Irving L Weissman

Jasper Jackson

Jayakumar Rajadas

William R Beasley

Joseph C Wu

Gerald G Fuller

Kemal Levi

Derrick C Wan

Charles K F Chan

Evgenia Mandrusov

C Travis Rappleye

Gordon Saul

Andrew Stephen Lee

Michael H Rosenthal

Mark A Kay

Kenneth N Horne

Keiichiro Ichiryu

Joseph Rimsa

Bankim H Mehta

Divya Nag

Sergio Salinas

Zhi-Ying Chen

Tor C Krog

Greg J Spooner

Michael T Cao

Manuel A Cardona Pamplona

Robert C Robbins

Paul W Burridge

Gerlinde Wernig

Feng Lan

Ning Sung

FangJun Jia

Nicholas Panetta

Deepak Gupta

Michael Januszyk

Ruth Tevlin

Melanie Harris

Kin Chan

Rene Rodriguez

Mimi Borrelli

Alessandra Laura Moore

Shamik Mascharak

Eun Young Seo

Heather E Talbott

Victor W Wong

Ning Sun

Jeffrey A Norton

Malini Chinta

Deshka Foster

Methods of reducing skin fibrosis by prophylactically treating skin prior to radiation therapy are described herein. The methods include applying an effective amount of DFO to skin that may be subjected to radiation, e.g., during treatment for cancer at a treatment site. The DFO may be administered transdermally.

Prophylactic skin treatment for radiation therapy

Methods of increasing perfusion and vascularity in irradiated tissue and of increasing retention of fat cells in a fat graft in irradiated tissue by applying an effective amount of DFO to the irradiated tissue at a treatment site. The DFO may be administered transdermally.

Conditioning irradiated tissue for increasing vascularity

A system and method for analyzing a plurality of tissue image samples at different stages of image processing in order to establish the level of fibrosis within a patient from which the tissue image sample was retrieved. Various embodiments incorporate machine learning techniques which enable an automated progressive approach to effectively and efficiently diagnosing fibrotic conditions based on tissue image samples.

Systems and methods for analyzing, detecting, and treating fibrotic connective tissue network formation

The methods, procedures, kits, and devices described herein assist with the healing process of tissue that was previously or simultaneously treated for a therapeutic or cosmetic effect. The methods, procedures, kits, and devices described herein can also provide temporary simulated results of a cosmetic procedure to allow for visual assessment to select the type of procedure or for treatment planning in advance of the surgical procedure.

Devices and methods for skin tightening

Methods and compositions are provided for the therapeutic use of hedgehog agents, for enhancing bone growth and regeneration in diabetic or pre-diabetic patients, including repair following injury, osseointegration of implants, and the like. In some embodiments of the invention, the compositions are administered locally, e.g. by injection or implantation at the site of an injury.

Reversing deficient hedgehog signaling restores deficient skeletal regeneration

Methods, compositions, and kits for producing functional blood vessels, and progenitors thereof are provided. Human disorders of the vascular system are treated by reconstitution of functional vessels in vivo through co-transplantation with supporting niche stromal cells for treatment of ischemic injury in the peripheral limbs and heart. The cell populations of the invention, when engrafted into a recipient, anastomose with host vasculature and regenerate functional blood vessels.

Identification and uses of vasculature forming progenitor cells and progenitor cell combinations

Methods of increasing perfusion and vascularity in irradiated tissue and of increasing retention of fat cells in a fat graft in irradiated tissue by applying an effective amount of DFO to the irradiated tissue at a treatment site. The DFO may be administered transdermally by applying a transdermal delivery device to a tissue surface at the treatment site in multiple discrete doses. The transdermal delivery system comprises DFO encapsulated in reverse micelles.

Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.

Skin treatment devices and methods with pre-stressed configurations

Methods, compositions and kits for producing functional chondrocytes, skeletal cells, bone marrow stromal cells, and progenitor cells thereof are provided. These methods, compositions and kits find use in producing chondrocytes, osteoblasts, stromal cells, and progenitor cells thereof in vivo, or in vitro for transplantation, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example for use in treating human disorders of the cartilage, bone and hematopoietic system. In some embodiments, specific combinations of protein factors are identified for reprogramming non-skeletal cells into bones, hematopoietic stroma, and chondrocytes, which may be provided in vitro or in vivo.

Factors and cells that provide for induction of bone, bone marrow, and cartilage

Devices, kits and methods are used for wound healing, including but not limited to the treatment, amelioration, or prevention of scars and/or keloids, and include packaging, manipulation elements, applicator and/or tensioning device that are used to apply and/or maintain a strain in an elastic dressing.

Controlled strain skin treatment devices and methods

Devices, kits, systems and methods are described herein for treatment to skin, including but not limited to wound healing, the treatment, amelioration, and/or prevention of scars or keloids. Certain devices kits, systems and methods are used to select treatment parameters, devices or methods for treating skin in a location, zone, or region of skin having particular mechanical or other properties.

Elastic devices, methods, systems and kits for selecting skin treatment devices

Devices, kits, systems and methods described herein may be for treatment to skin, including but not limited to wound healing, the treatment, amelioration, and/or prevention of scars or keloids. Devices kits, systems and methods described herein may be used to select treatment parameters or devices for treating skin in a zone or region of skin having particular mechanical or other properties.

Devices, methods, systems and kits for selecting skin treatment devices

The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) activity or expression. Blockade of FAK is sufficient to prevent mechanical and inflammatory stimuli from activating MCP-1 pathways. In addition to these chemokine-mediated mechanisms, inhibition of FAK may control fibrosis by blocking fibroblast collagen production. Pharmacologic blockade of FAK significantly reduces scar formation in vivo.

Inhibition of focal adhesion kinase for control of scar tissue formation

Human somatic cells obtained from individuals with a genetic heart condition are reprogrammed to become induced pluripotent stem cells (iPS cells), and differentiated into cardiomyocytes for use in analysis, screening programs, and the like.

Cardiomyocytes from induced pluripotent stem cells from patients and methods of use thereof

Growing community of inventors

Atherton, CA, United States of America

Michael T Longaker