Mayo Foundation for Medical Education and Research

The Translational Genomics Research Institute

Michael T Barrett

Mitesh J Borad

Ramesh K Ramanathan

Elizabeth Lenkiewicz

Barbara A Pockaj

Karen S Anderson

Tara Holley

This document provides methods and materials involved in assessing cancer (e.g., breast cancer). For example, methods and materials for determining whether or not a cancer patient (e.g., a breast cancer patient) having ER&#x2212;/PgR&#x2212;/HER2&#x2212; cancer cells is likely to have a favorable or unfavorable outcome and/or is likely to respond a cancer treatment that includes a PD-1 inhibitor and/or PD-L1 inhibitor in combination with a JAK2 inhibitor are provided. Methods and materials involved in treating mammals having ER&#x2212;/PgR&#x2212;/HER2&#x2212; cancer (e.g., ER&#x2212;/PgR&#x2212;/HER2&#x2212; breast cancer) by administering a PD-1 inhibitor and/or PD-L1 inhibitor in combination with a JAK2 inhibitor also are provided.

Methods and materials for assessing and treating cancer

The present invention relates to a system and method of genomic profiling and is particularly useful in genomic differentiation of heterogeneous and polyclonal neoplastic cell populations, preferably of flow sorted formalin fixed paraffin embedded samples. The present invention includes methods of improving resolution for identifying aberration in variable carcinoma genomes and/or heterogeneous cell populations. The present invention also includes kits configured to improve genomic resolution and the ability to identify genomic aberration in variable and/or heterogeneous cell populations.

System and method of genomic profiling

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Scottsdale, AZ, United States of America

Michael T Barrett