Seattle Genetics, Inc.

Seagen Inc.

Road Runner Holdco LLC

Michael Sun

Kenneth Gould

Eric Sievers

Dana Kennedy

Stephen C Alley

Damon L Meyer

Nathan Ihle

Feng Huang

Damon Meyer

Stephen Charles Alley

Joo C Chung

Disclosed are methods of purifying mixtures comprising benzoidiazepine antibody-drug conjugates.

Activated carbon filtration for purification of benzodiazepine ADCs

Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula (I); or a pharmaceutically acceptable salt thereof; wherein: mAb is an anti-CD30 antibody unit, S is a sulfur atom of the antibody, A- is a Stretcher unit, and p is from about 3 to about 5. 

Weekly dosing regimens for anti-CD30 VC-PAB-MMAE antibody drug-conjugates

A protein containing one or more activatable groups, e.g., an antibody, is subjected to partial or complete reduction of one or more such bonds to form reactive groups; the resulting protein is reacted with a drug which is reactive with some of the reactive groups, such as certain radiometals, chelating agents, and toxins, so as to form a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.

Partially loaded antibodies and methods of their conjugation

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Bothell, WA, United States of America

Michael Sun