Max-Planck-Gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Olympus Corporation

Asea Brown Boveri Ag

Evotec Oai Ag

Michael Stuke

Karsten Henco

Manfred Eigen

Wolfgang Simm

Rudolf Rigler

Ulo Mets

Jerker Widengren

Michael Brinkmeyer

Olaf Lehman

Olaf Lehmann

Georg F Wahl

Fritz P Schafer

Hilmar Esrom

Oliver Gottsleben

Horst-Christian Langowski

Tobias Damm

Stefan Preuss

A Method for identifying one or a small number of molecules, especially in a dilution of &#x2266;1 &#x3bc;M, using laser excited FCS with measuring times &#x2266;500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably &#x2266;10l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined. The device which can be preferably used for performing the method according to the invention is a per se known system of microscope optics for laser focusing for fluorescence excitation in a small measuring compartment of a very diluted solution and for imaging the emitted light in the subsequent measurement through confocal imaging wherein at least one system of optics with high numerical aperture of preferably &#x2267;1.2 N.A. is employed, the light quantity is limited by a confocally arranged pinhole aperture in the object plane behind the microscope objective, and the measuring compartment is positioned at a distance of between 0 and 1000 &#x3bc;m from the observation objective.

Method and a device for the evaluation of biopolymer fitness

A method for identifying one or a small number of molecules, especially in a dilution of &lE;1 &mgr;M, using laser excited FCS with measuring times &lE;500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably &lE;10 l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined.

Process and device for production of three-dimensional structures

In a method for recording information in an optical data memory by surface exturing, a substrate surface is first pre-treated or sensitized by selective irradiation at relatively low fluence. For selectivity of irradiation, a mask, a holographic imaging process, or direct writing may be used. In a second step, the sensitized regions are ablated from the surface by means of spatially non-selective irradiation at a different wavelength and at relatively high fluence.

Method for recording information in an optically readable data memory

CVD method for depositing a layer on an electrically conductive thin

A method for producing full-surface or partial metal films on a substrate includes placing a coating on a substrate. The coating is irradiated sheetwise with a laser to form the metal films.

Method for producing metal films

A laser mass spectrometer comprises an electrode system and an ion detector system supported on a mounting flange. The electrode system defines an ionization space, an ion acceleration space and a time-of-flight or separation path. At least some of the electrode of the electrode system are removably mounted on support rods extending an axial or ion path direction, to allow accomodation of the distance between the ionization space and the mounting flange to the configuration of an apparatus or vacuum system with which the mass spectrometer is used. Thus, the distance between the mounting flange and the ionization space may be varied by using separation path of different length. The ionization is effected by laser radiation, which may be coupled in through a window in the mounting flange. To derive additional information about a substance under investigation, means may be provided for coupling out radiation emitted by the ionized substance in the ionization space, and the laser may provide radiation pulses having a length in the order of picoseconds, as 10 ps and less, to avoid fragmentation of larger molecules which would prevent detection of the 'parent ion'.

Laser mass spectrometer

A method of photochemical separation of isotopes, wherein molecules containing differing isotopes to be separated are selectively excited by laser radiation, and the excited molecules are collectively reacted with a scavenger which is relatively inert to molecules of lesser excitation, the reaction producing a stable addition product which is readily isolatable.

Method of photochemical separation of isotopes

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Gottingen, Germany

Michael Stuke