Q32 Bio Inc.

Monsanto Technology LLC

Harvard College

Michael Storek

Justin Andrew Caravella

Frederick Robbins Taylor

Susan L Kalled

Shelia Marie Violette

Vernon Michael Holers

Ellen Garber Stark

Michael Steven Curtis

Kelly C Fahnoe

Cheng Ran Huang

Gregory Lawrence Verdine

Jacqueline E Heard

Sara Ann Salvador

Paolo Castiglioni

Robert M McCarroll

Christopher P Bonin

Robert L D'Ordine

Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.

Methods of treating complement mediated diseases with fusion protein constructs comprising anti-C3d antibody and a complement modulator

Fusion protein constructs comprising anti-C3d antibody and CR1 polypeptide

Fusion protein constructs comprising anti-C3d antibody and factor H

Disclosed herein are novel variant bacterial cold shock proteins and recombinant DNA for expressing such proteins to produce transgenic plants with enhanced stress tolerance and/or enhanced yield.

Stress tolerant transgenic crop plants

Uridine analogs and techniques for making and using uridine analogs are disclosed in this invention. These uridine analogs include nucleoside phosphates having a 5-aminouracil group. These nucleotides can be incorporated into a nucleic acid as an unnatural base, as a substitute for uridine or thymine. The nucleic acid can then be treated with an oxidizing agent and an alkaline solution, which causes cleavage of the nucleic acid at the position of the unnatural base. The nucleoside phosphate analogs can be used in many ways, including measuring chemical interactions between nucleic acids and other compounds, or sequencing nucleic acids. Additional compounds can also be derivitized onto the amino group, allowing other functionalities to be added to the nucleoside phosphate, or to the nucleic acid incorporating the nucleoside phosphate.

Uridine analogs and techniques for making and using

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Cambridge, MA, United States of America

Michael Storek