Q32 Bio Inc.

Other

Michael Steven Curtis

Justin Andrew Caravella

Frederick Robbins Taylor

Susan L Kalled

Shelia Marie Violette

Vernon Michael Holers

Michael Storek

Ellen Garber Stark

Kelly C Fahnoe

Cheng Ran Huang

Robert W Weeks, Jr

Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.

Methods of treating complement mediated diseases with fusion protein constructs comprising anti-C3d antibody and a complement modulator

Fusion protein constructs comprising anti-C3d antibody and CR1 polypeptide

Fusion protein constructs comprising anti-C3d antibody and factor H

The apparatus includes a device adapted for removing contaminated air from a controlled area, cleansing this air using suitable filtration devices, and returning air having a safe level of contaminants mixed with a portion of fresh air or solely fresh air to the controlled area. The apparatus further includes barrier means for preventing contaminants from exiting the controlled area except through the air removal device which can be located either inside or outside of the controlled area.

Apparatus for ventilating controlled areas

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Waltham, MA, United States of America

Michael Steven Curtis