Dsm Fine Chemicals Austria Nfg Gmbh & Co. Kg

Actelion Pharmaceuticals Ltd

Dsm IP Assets B.v.

Dsm Fine Chemcials Nfg Gmbh & Co Kg

Dpx Fine Chemicals Austria Gmbh & Co Kg

Michael Stanek

Felix Spindler

Helmut Schwab

Ralf Koberstein

Wolfgang Skranc

Peter Hildebrand

Zarghun Nazir

Walter Raml

Erich Steinwender

Wilhelm Tschebull

Christoph Imboden

Doris Domin

Matthias Helms

Monika Knopp

Stefan Essl

Andreas Hendrikus Maria De Vries

Gerardus Karel Maria Verzijl

Gerhard Steinbauer

Erhard Bappert

Marcel G Wubbolts

Harald Pichler

Gerald Summer

Marion Wagner

Curt Zimmermann

Gerhard Schoppel

Georg Haeubl

Peter Pojarliev

Georg Häubl

Christoph Zenzmaier

Ernst Wressnegger

Manuela Hermann

Joannes Kierkels

Marianne Castelijns

Regina Schitter

Jurgen Stichler

Ralph Koberstein

Maria Andreas Hendrikus De Vries

Erwin Kübel

Maria Gerardus Karel Verzijl

Marcel Wubbolts

Gerardus Karel Verzijl

Andreas Hendrikus De Vries

Georg Haubl

Erwin Kubel

Erwin Kuebel

Improved method of production of 9-(Z)-retinoic acid, in which a) a &#x3b2;-formyl-crotonic acid C-Calkyl or phenyl ester is reacted with an isolated 9-(Z)&#x2014;C-triarylphosphonium salt by the Wittig reaction in the presence of a base to the corresponding 9-(Z)-retinoic acid ester; which b) is then saponified with a base to the corresponding 9-(Z)-retinoic acid carboxylate and then, following protonation with an acid, the desired 9-(Z)-retinoic acid is obtained, and improved method for the enrichment and isolation of the 9-(Z)&#x2014;C-triarylphosphonium salt.

Method of production of 9-cis-retinoic acid

The present invention relates to a process for the preparation of the compound of formula (7) which process comprises the hydrogenation of the compound of formula (4) using bis[chloro-1,5-cyclooctadiene-iridium], (S)-i-dicyclohexylphosphino-2-[(S)-&#x3b1;-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]-ferrocene as a catalyst. 

Process for the preparation of an enantiomeric trisubstituted 3,4-dihydro-isoquinoline derivative

The present invention relates to the compound of formula 7*acetate (see below), a process for its preparation, and its use 

Trisubstituted 3,4-dihydro-1H-isoquinolin compound, process for its preparation, and its use

The invention relates to a method for alkylating cross-linked polymers containing N- or amino, ammonium or spiro-bicyclic ammonium groups. According to said method, the gelated polymers, obtained by polymerization and cross-linking, are a) optionally, deprotonated in water, an organic solvent or in a mixture of an organic solvent and water, by adding a base, b) optionally, washed once or more with water, an organic solvent or a mixture of an organic solvent and water, then c) one or more alkylators are added to the gel suspension which is stirred in water, an organic solvent or in a mixture of an organic solvent and water, at a temperature of between 5 and 160&#xb0; C. at normal or increased pressure, with a base being added after a short mixing time and d) reprotonation is carried out using a mineral acid, optionally after one or more washing steps, resulting in the alkylated, cross-linked polymers containing N- or amino, ammonium or spirobicyclic ammonium groups, accordingly.

Alkylation of crosslinked polymers containing N or amino or ammonium groups

Process for the preparation of alkylated N- or amino, ammonium or spirobicyclic ammonium group-containing, crosslinked polymer gels, which is characterized in that

Preparation of alkylated N- or amino, ammonium or spirobicyclic ammonium group-containing, crosslinked polymers

Process for the drying of polymers containing N or amino, ammonium or spirobicyclic ammonium groups, comprising cationic N-containing groups, and suitable counterions, in which the gelled and washed polymers obtained by polymerization, crosslinkage and optionally alkylation are dried continuously using a gaseous medium under normal pressure or overpressure in a fluidized bed.

Process for the continuous drying of polymers containing N or amino, ammonium or spirobicyclic ammonium groups

The invention relates to a method for the production of 2-coumarone or substituted 2-coumarones, whereby cyclohexanone or substituted cyclohexanone is reacted with a carboxyl-containing acylating agent a) to give methyl 2-(2-oxo-cyclohexyl)-2-hydroxyacetate or substituted methyl 2-(2-oxo-cyclohexyl)-2-hydroxyacetates, which are either a) directly converted to 2-coumarone or substituted 2-coumarones by means of catalytic gas-phase dehydrogenation, or a) dehydrated by means of azeotropic distillation under basic conditions, or by use of a strong acid, or a strongly acidic ion exchanger to a mixture of methyl 2-oxocyclohexylidenacetate and the enol-lactone of the 2-oxocyclohexylidenacetic acid, or a mixture of substituted methyl 2-oxocyclohexylidenacetate and the enol-lactone of the substituted 2-oxocyclohexylidenacetic acid, which is finally converted in turn by catalytic gas-phase dehydrogenation to 2-coumarone, or substituted 2-coumarones, or b) are directly converted under acidic or basic conditions into a mixture of methyl 2-oxocyclohexylidenacetate and the enol-lactone of 2-oxo-cyclohexylidenacetic acid, or a mixture of substituted methyl 2-oxocyclohexylidenacetate and the enol-lactone of the substituted 2-oxo-cyclohexylidenacetic acid, which is finally converted in turn by catalytic gas-phase dehydrogenation into 2-coumarone or substituted 2-coumarones.

Method for the production of 2-coumarone and substituted 2-coumarones

The invention relates to a washing process for cleaning polymers containing N or amine, ammonium or spirobicyclic ammonium groups, comprising cationic groups containing N, in addition to suitable counterions, whereby the gelled-out polymers are obtained through polymerization and cross-linking by a) adding a base which is partially or fully deprotonated, b) the partially or fully deprotonated polymers are washed, then c) optionally, are reprotonated in an organic solvent or in an organic solvent/water mixture by adding an acid, whereupon d) optionally, they are washed in an organic solvent or an organic solvent/water mixture in order to shrink the gels and optionally, e) in connection with step c) or d), the steps a)-c) or -d) are repeated.

Washing process for the purification of polymers containing N or amino, ammonium or spirobicyclic ammonium groups

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Linz, Austria

Michael Stanek