University of Michigan

Michael Skoumal

Lonnie D Shea

Ryan Pearson

Tadas Kasputis

The disclosure provides a method of preparing a polymer scaffold including admixing a biotinylated reagent and a polymer to form a biotinylated polymer, subjecting the biotinylated polymer to conditions sufficient to form the polymer scaffold and optionally admixing the polymer scaffold with a streptavidin-modified biomolecule to form a biomolecule-modified polymer scaffold. The disclosure further provides a method of preparing a polymer scaffold including admixing a first click chemistry reagent and a poly(lactic-co-glycolic acid) (PLGA) polymer to form a modified PLGA polymer, subjecting the modified PLGA polymer to conditions sufficient to form the polymer scaffold, and optionally admixing the polymer scaffold with a biomolecule modified to include a second click chemistry reagent that selectively reacts with the first click chemistry reagent, to form a biomolecule-modified polymer scaffold.

Functionalization of polymer scaffolds

The present disclosure relates generally to biomaterial implants and methods for delivering a cell to an individual in need thereof and, more particularly, to biomaterial implants and techniques for delivering islets and/or &#x3b2;-cell progenitors to an individual.

Growing community of inventors

Ann Arbor, MI, United States of America

Michael Skoumal